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Start Over Author "Jandová R" Topic myocardial infarction
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3. Hemodynamic effects of acute digitalization several months after acute myocardial infarction.

Author

Ressl J, Jandová R, Jebavý P, Kasalický J, and Widimský J

Subjects
Acute Disease, Adult, Aged, Blood Pressure drug effects, Cardiac Output drug effects, Clinical Trials as Topic, Drug Evaluation, Heart Rate drug effects, Heart Ventricles drug effects, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Myocardial Infarction physiopathology, Physical Exertion, Digoxin therapeutic use, Hemodynamics drug effects, Myocardial Infarction drug therapy
Abstract

Left ventricular function was investigated at rest and during exercise by heart catheterization in 15 patients 3-5 months after acute myocardial infarction. The effect of 1 mg digoxin i.v. in ten patients was correlated to placebo (saline solution) in five patients. A significant decrease of the left ventricular enddiastolic pressure, increase of left ventricular systolic ejection fraction and a shift of the left ventricular function curve to left upwards was found after digoxin with no changes in the placebo group. This beneficial effect of acute digitalization in patients convalescing from uncomplicated myocardial infarction without clinical signs of manifest heart failure could have therapeutic implication.

Published
1975
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