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2 results on '"Kinev AV"'

1. [A method for determining the constitutive and inducible forms of a heat-shock protein of 70 kDa in the human myocardium and lymphocytes].

Author

Karpishchenko AI, Demidov ON, Tyrenko VV, Komarova EIu, Kinev AV, and Margulis BA

Subjects
Adolescent, Adult, Aged, Child, Electrophoresis, Polyacrylamide Gel methods, Female, HSP70 Heat-Shock Proteins isolation & purification, HSP72 Heat-Shock Proteins, Heat-Shock Proteins analysis, Heat-Shock Proteins isolation & purification, Humans, Immunoblotting methods, Male, HSP70 Heat-Shock Proteins analysis, Lymphocytes chemistry, Myocardium chemistry
Published
2000

2. [Role of heat-shock proteins in cardioprotection of patients operated on for ischemic heart disease].

Author

Shevchenko IuL, Demidov ON, Tyrenko VV, Svistov AS, Belevitin AB, Karpishchenko AI, Komarova EIu, Popova TV, Kinev AV, and Margulis BA

Subjects
Adult, Aged, Aorta surgery, Biopsy, Cardiopulmonary Bypass, Creatine Kinase blood, Data Interpretation, Statistical, Electrophoresis, Polyacrylamide Gel, HSP70 Heat-Shock Proteins analysis, HSP70 Heat-Shock Proteins biosynthesis, HSP70 Heat-Shock Proteins physiology, Heat-Shock Proteins analysis, Heat-Shock Proteins biosynthesis, Humans, Immunoblotting, Male, Middle Aged, Myocardial Reperfusion Injury physiopathology, Myocardium metabolism, Time Factors, Coronary Artery Bypass, Coronary Disease surgery, Heat-Shock Proteins physiology, Myocardium chemistry
Abstract

Major stress protein HSP72 is known to participate in protecting cells and organisms against harmful factors including ischemia, trauma etc. Under study was the level of HSP72 in the myocardium of 32 patients with coronary disease operated in Military-medical academy. HSP72 was detected in probes of the right atria before and after pre-cardiopulmonary bypass in all cases induction of HSP72 was observed in 40% of patients, and directly correlated with the time of cardiopulmonary bypass and standing of the disease. The cardioprotective effect of the elevated pre-operational level of HSP72 was shown to be proportionate to the lower activity of cardiospecific enzymes, creatine phosphokinase (CK-MB). It is suggested that HSP72 is involved in the mechanism of cardioprotection during cardiopulmonary bypass.

Published
1999

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