Search

A study was made of effects of transcardiac galvanization (TCG) on activities of a panel of oxidation-reduction enzymes as well as on the cardiac muscle content of high energy substrates, and size of the lesion area, in experimental myocardial infarction (EMI) in 50 albino male rats. After two TCG procedures, and at 24-h EMI, augmentation was found of activities of succinic dehydrogenase, lactate dehydrogenase, NADH-dehydrogenase, beta-hydroxybutyrate dehydrogenase, both in the area of profound ischemia and peri-infarction myocardium, this being accompanied with an increase in myocardial content of adenosine triphosphate, creatine phosphate, and glycogen, and reduction of the developing mass of necrosis. Stimulation of enzyme activity in the course on the enzyme complex and membrane-stabilizing action of this preformed physical factor.

Activity of ATPase in functional element of myocardium (its qualitative and quantitative aspects) has been researched in normal tissue and in one with various levels of hypothermic ischemia (28-30 degrees C and 10-12 degrees C) by methods of electron microscopic histochemistry on dogs. It has been found that hypothermia of myocardium (10-12 degrees C) optimally prevents ischemic disorders of energetic processes. Reproduction activity of ATPase during reperfusion of myocardium after that hypothermia maintains contractile function of heart in proper high level.

The state of main structures of the functional element of the canine myocardium has been estimated at ether-oxygen narcosis. Heterogeneity of blood supply, histological and histochemical organization of the myocardium depends on its topological differentiation.