1. Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2.
- Author
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Burnett, Joseph W. H., Li, Jianwei, McCue, Alan J., Kechagiopoulos, Panagiotis N., Howe, Russell F., and Wang, Xiaodong
- Subjects
- *
NAD (Coenzyme) , *HETEROGENEOUS catalysts , *NICOTINAMIDE , *CATALYSTS , *TIN - Abstract
H2-Driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at% Sn can deliver a selectivity of 90% (at full conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4-position of the nicotinamide ring. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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