1. Effect of naltrexone administration on short-term memory in chronically ethanol-treated outbred rats.
- Author
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Okulicz-Kozaryn I, Mikolajczak P, Kaminska E, Kaminska I, Szulc M, and Bobkiewicz-Kozlowska T
- Subjects
- Analysis of Variance, Animals, Dose-Response Relationship, Drug, Male, Naltrexone administration & dosage, Narcotic Antagonists administration & dosage, Rats, Rats, Wistar, Ethanol administration & dosage, Memory, Short-Term drug effects, Naltrexone pharmacology, Narcotic Antagonists pharmacology
- Abstract
Aims: The purpose of this study was to evaluate the effect of naltrexone treatment for 21 consecutive days on short-term memory in ethanol-preferring and non-preferring outbred rats., Methods: Ethanol preferring, non-preferring and control Wistar rats were treated with naltrexone [0.1 mg/kg intraperitoneally (i.p.)] for 21 consecutive days. Short-term memory was assessed by using an olfactory social recognition test., Results: A single administration of naltrexone (0.1 mg/kg i.p.) to non-ethanol-treated animals facilitated social memory, whereas the drug did not affect short-term memory in either group of chronically ethanol-treated rats. Multiple naltrexone treatment also lowered alcohol intake in ethanol-preferring rats., Conclusion: Naltrexone-ethanol interaction does not seem to produce any negative effect on the short-term memory in outbred rats.
- Published
- 2004
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