1. Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment.
- Author
-
Pinheiro WO, Costa do Santos MS, Farias GR, Fascineli ML, Ramos KLV, Duarte ECB, Damasceno EAM, da Silva JR, Joanitti GA, de Azevedo RB, Sousa MH, Lacava ZGM, Mosiniewicz-Szablewska E, Suchocki P, Morais PC, and de Andrade LR
- Subjects
- Animals, Breast Neoplasms pathology, Carcinoma, Ehrlich Tumor pathology, Carcinoma, Ehrlich Tumor therapy, Cell Cycle drug effects, Combined Modality Therapy, DNA Fragmentation drug effects, Female, Magnetite Nanoparticles chemistry, Magnetite Nanoparticles ultrastructure, Mice, Nanocapsules chemistry, Nanocapsules ultrastructure, Selenium Compounds chemistry, Time Factors, Treatment Outcome, Tumor Burden drug effects, Breast Neoplasms therapy, Hyperthermia, Induced, Magnetite Nanoparticles therapeutic use, Nanocapsules therapeutic use, Selenium Compounds therapeutic use
- Abstract
Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged., (© 2022 IOP Publishing Ltd.)
- Published
- 2022
- Full Text
- View/download PDF