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Nanocomposite membranes are a class of membranes that integrate the characteristics of both inorganic and organic materials. The tunable properties of these membranes have led to the development of different separation processes in a variety of fields like wastewater treatment, seawater desalination, food industry, biotechnology, oil and gas, pharmaceutical, and dairy industry. Adding nanofillers with certain functionalities to polymer matrices can improve permeation and separation properties; fouling resistance; thermal conductivity; and the mechanical, thermal, and chemical stability of resulting membrane. There are few commercial-scale applications of nanocomposite membranes reported in the literature. However, this chapter aims to provide the potential prospects of nanocomposite membranes in commercial scale.