1. Novel nanofiltration membrane prepared by amphiphilic random copolymer nanoparticles packing for high-efficiency biomolecules separation.
- Author
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Yu, Wen-Han, Qiu, Ze-Lin, Wang, Jia-Rong, Shen, Yu-Jie, Han, Jun, Fang, Li-Feng, and Zhu, Bao-Ku
- Subjects
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POLYMERIZATION , *EMULSION polymerization , *NANOFILTRATION , *BIOMOLECULES , *METHYL methacrylate , *POROSITY , *NANOPARTICLES - Abstract
[Display omitted] • Permeation channel was constructed via amphiphilic copolymer nanoparticles packing. • The copolymer nanoparticles were prepared by soap-free emulsion polymerization. • The membrane showed the high selectivity towards amino acids and biopeptides. • This method simplified preparation of NF membrane via nanoparticles packing route. Nanofiltration (NF) as a promising candidate is widely used in charge-based separation of ampholytic biomolecules. Construction of strongly charged permeation channel of NF membrane is one of the key factors for this process. In this work, random amphiphilic copolymer (RACP) nanoparticles were first packed to prepare nanoscale permeation channel. The RACP emulsion was firstly prepared by soap-free emulsion polymerization between [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (DMC) and methyl methacrylate (MMA), and then directly depositing onto porous substrate to form nanochannel selective layer of NF membrane. The optimal NF membrane shows a relatively large pore structure (i.e., cut-off pore size is 1.43 nm) and high pure water permeance (PWP) of 13.3 L·m−2·h−1·bar−1. Moreover, it shows a desirable rejection of basic amino acids and biopeptides (i.e., ∼95%) and allows neutral or acidic ones with similar molecule weight to permeate through. This work provides an innovative and facile method directly from RACP emulsion to construct NF membrane via nanoparticle packing, which greatly simplifies the preparation procedure for NF membrane. In addition, this novel NF membrane also demonstrates great potential in charge-based separation of biomolecules. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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