1. Promotion of the transdermal delivery of protein drugs by N -trimethyl chitosan nanoparticles combined with polypropylene electret.
- Author
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Tu Y, Wang X, Lu Y, Zhang H, Yu Y, Chen Y, Liu J, Sun Z, Cui L, Gao J, and Zhong Y
- Subjects
- Administration, Cutaneous, Animals, Anti-Inflammatory Agents chemistry, Drug Delivery Systems, Edema metabolism, Edema pathology, Gels, Ions, Keratins metabolism, Male, Mice, Mice, Inbred BALB C, Microscopy, Confocal, Nanomedicine methods, Particle Size, Proteins, Rats, Rats, Sprague-Dawley, Superoxide Dismutase chemistry, Superoxide Dismutase metabolism, Chitosan chemistry, Drug Carriers pharmacology, Nanoparticles chemistry, Polypropylenes chemistry, Skin drug effects
- Abstract
We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N -trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret. The results showed that in the presence of electret, the transdermal delivery of protein drugs in TMC NPs was significantly enhanced, as demonstrated by in vitro permeation studies and confocal laser scanning microscopy. Notably, superoxide dismutase-loaded TMC NPs combined with electret exhibited the best inhibitory effect on the edema of the mouse ear. TMC NPs combined with electret represent a novel platform for the transdermal delivery of protein drugs., Competing Interests: The authors report no conflicts of interest in this work.
- Published
- 2016
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