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Your search keyword '"Viktor Chikan"' showing total 4 results
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4 results on '"Viktor Chikan"'

1. Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Author

Gayani Abayaweera, Viktor Chikan, Raj Kumar Dani, Olga Koper, Marla Pyle, Gwi-Moon Seo, Hongwang Wang, Sivasai Balivada, Matthew T. Basel, Deryl L. Troyer, Stefan H. Bossmann, Tej B. Shrestha, and Masaaki Tamura

Subjects
Pathology, medicine.medical_treatment, Cell, pancreatic cancer, Pharmaceutical Science, Transplants, 02 engineering and technology, Ferric Compounds, chemistry.chemical_compound, Mice, 0302 clinical medicine, International Journal of Nanomedicine, Drug Discovery, Original Research, General Medicine, 021001 nanoscience & nanotechnology, 3. Good health, Survival Rate, medicine.anatomical_structure, 030220 oncology & carcinogenesis, disseminated peritoneal carcinomatosis, 0210 nano-technology, Iron oxide nanoparticles, Hyperthermia, medicine.medical_specialty, Materials science, Intraperitoneal injection, Biophysics, Bioengineering, Biomaterials, 03 medical and health sciences, Magnetics, targeted magnetic hyperthermia, Pancreatic cancer, medicine, Animals, Monocyte, Macrophages, Organic Chemistry, Cancer, Hyperthermia, Induced, medicine.disease, Pancreatic Neoplasms, Disease Models, Animal, Magnetic Fields, chemistry, Cancer research, Magnetic nanoparticles, Nanoparticles, cytotherapy
Abstract

Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticles

Published
2012

2. Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells

Author

Stefan H. Bossmann, Carl B. Myers, Xiaoxuan Leaym, Raja Shekar Rachakatla, Masaaki Tamura, Thilani N. Samarakoon, Hongwang Wang, Viktor Chikan, Sivasai Balivada, Franklin Orban Kroh, Gwi-Moon Seo, Olga Koper, Marla Pyle, Deryl L. Troyer, Brandon Walker, and Raj Kumar Dani

Subjects
Proteomics, Materials science, Iron, Magnetic Field Therapy, General Physics and Astronomy, Nanotechnology, Ferric Compounds, Nervous System, Article, Mice, Cell Line, Tumor, medicine, Animals, Humans, General Materials Science, Viability assay, Cytotoxicity, Melanoma, Stem Cells, Electric Conductivity, Temperature, General Engineering, Biological Transport, medicine.disease, Neural stem cell, Magnetic hyperthermia, Biophysics, Nanoparticles, Magnetic nanoparticles, Female, Stem cell, Stem Cell Transplantation
Abstract

Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane-porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p

Published
2010

3. Synthesis of Water-Soluble Iron−Gold Alloy Nanoparticles.

Author

Naween Dahal, Jacek Jasinski, Valerie J. Leppert, and Viktor Chikan

Subjects
*NANOPARTICLES, *PARTICLES, *NANOCRYSTALS, *IRON
Abstract

In this study, a synthetic method to produce water-soluble iron−gold (Fe−Au) alloy nanoparticles is described. The diameter of the alloy nanoparticles is 4.9 ± 1.0 and 3.8 ± 1.0 nm for two different precursors of iron, ferrous sulfate heptahydrate (Fe 2+) and iron pentacarbonyl (Fe 0). The X-ray powder diffraction of the alloyed nanoparticles shows an appreciable shift in 2θ peak positions relative to pure gold or iron. Using Vegard’s law, we estimated the particle’s iron content to be 14.8 ± 4.7 mol %. The lattice constant of the alloy nanoparticles is found to be 4.0449 ± 0.0375 Å. The high-resolution transmission electron microscopy images show the presence of icosahedral structures in agreement with the previous high temperature synthesis of the Fe−Au alloy nanoparticles. The optical absorption of the alloy nanoparticles is distinctive from pure gold nanoparticles and shows a relatively narrow absorption band in the range of 642−662 nm depending upon the amount of gold precursor used. [ABSTRACT FROM AUTHOR]

Published
2008
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4. MspA Porin−Gold Nanoparticle Assemblies: Enhanced Binding through a Controlled Cysteine Mutation.

Author

Raj Kumar Dani, Myungshim Kang, Mausam Kalita, Paul E. Smith, Stefan H. Bossmann, and Viktor Chikan

Subjects
*NANOPARTICLES, *MYCOBACTERIUM, *PHOTOLUMINESCENCE, *ENERGY transfer
Abstract

In this study, the interactions of two gold nanoparticles of different sizes (average diameters of 3.7 ± 2.6 and 17 ± 3 nm) with octameric mycobacterial porin A from Mycobacterium smegmatis(MspA) and a mutant of MspA featuring a cysteine mutation in position 126 (Q126C) are investigated. From the observation of enhanced photoluminescence quenching, it is inferred that the presence of eight cysteines in the MspA Q126C mutant significantly enhances the binding of selected small gold nanoparticles within the inner pore of MspA. The large gold nanoparticle/porin complex shows photoluminescence enhancement, which is expected since the larger nanoparticles cannot dock within the homopore of MspA due to size exclusion. In addition to the fluorescence experiments, observation of energy transfer from the small gold nanoparticles to the MspA shows the close proximity of the small gold nanoparticles with the porin. Interestingly, the energy transfer of the large nanoparticle/MspA complex is completely missing. From high-performance liquid chromatography data, the estimated binding constants for small Au@MspA, large Au@MspA, small Au@MspA cys, and large Au@MspA cysare 1.3 × 10 9, 2.22 × 10 10, > 10 12(irreversible), and 1.7 × 10 10, respectively. [ABSTRACT FROM AUTHOR]

Published
2008
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