1. Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer.
- Author
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Guan Q, Li Y, Zhang H, Liu S, Ding Z, Fan Z, Wang Q, Wang Z, Han J, Liu M, and Zhao Y
- Subjects
- Cell Line, Tumor, Female, Humans, Lasers, Paclitaxel, Photosensitizing Agents pharmacology, Photosensitizing Agents therapeutic use, Breast Neoplasms drug therapy, Chlorophyllides therapeutic use, Nanoparticles, Photochemotherapy, Porphyrins pharmacology
- Abstract
Herein, novel laser-responsive multi-functional nanoparticles (NPs-Lip@PTX/CyA/Ce6) were fabricated with bovine serum albumins (BSA) based nanoparticles, which simultaneously carried chemotherapeutic drug paclitaxel (PTX) and P-gp inhibitor cyclosporin A (CyA), as core and photosensitizer agent Chlorin e6 (Ce6) loaded Tf-modified liposomal bilayer as shell. NPs-Lip@PTX/CyA/Ce6 exhibited apparent core-shell structure morphology with particle size of 160.9 ± 1.7 nm and zeta potential of - 26.7 ± 0.6 mV, indicating their excellent stability in aqueous solution. Besides, NPs-Lip@PTX/CyA/Ce6 possessed laser-responsive release profiles upon laser irradiation at specific wavelength, which was favor to exert efficient combinatorial chemo-photodynamic therapy and effectively reverse the multiple drug resistance (MDR). Under laser irradiation, as expected, NPs-Lip@PTX/CyA/Ce6 demonstrated superb intracellular ROS productivity and fantastic in vitro and in vivo anti-cancer therapy effect but absent of systemic toxicity. In conclusion, the nano-drug delivery system would be prospectively applied in clinic as resultful therapeutic tactic for investing compositional chemo-photodynamic therapy synergistically., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
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