1. Biomarkers of nanomaterials hazard from multi-layer data.
- Author
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Fortino, Vittorio, Kinaret, Pia Anneli Sofia, Fratello, Michele, Serra, Angela, Saarimäki, Laura Aliisa, Gallud, Audrey, Gupta, Govind, Vales, Gerard, Correia, Manuel, Rasool, Omid, Ytterberg, Jimmy, Monopoli, Marco, Skoog, Tiina, Ritchie, Peter, Moya, Sergio, Vázquez-Campos, Socorro, Handy, Richard, Grafström, Roland, Tran, Lang, and Zubarev, Roman
- Subjects
NANOSTRUCTURED materials ,TOXICITY testing ,BIOMARKERS ,MATERIALS testing ,HAZARDS - Abstract
There is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro and in vivo models. Our methodology allows for the grouping of ENMs based on multi-omics approaches combined with robust toxicity tests. Importantly, we identify mRNA-based toxicity markers and extensively replicate them in multiple independent datasets. We find that models based on combinations of omics-derived features and material intrinsic properties display significantly improved predictive accuracy as compared to physicochemical properties alone. Nanomaterials have a range of potential applications, however, toxicity remains a concern, limiting application and requiring extensive testing. Here, the authors report on a predictive framework made using a range of tests linking materials properties with toxicity, allowing the prediction of toxicity from physiochemical and biological properties. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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