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Your search keyword '"Simonato, Jean-Pierre"' showing total 3 results
Start Over Author "Simonato, Jean-Pierre" Topic nanotechnology
3 results on '"Simonato, Jean-Pierre"'

1. Crumpling of silver nanowires by endolysosomes strongly reduces toxicity

Author

Lehmann, Sylvia G, Toybou, Djadidi, del Real, Ana-Elena Pradas, Arndt, Devrah, Tagmount, Abderrahmane, Viau, Muriel, Safi, Malak, Pacureanu, Alexandra, Cloetens, Peter, Bohic, Sylvain, Salomé, Murielle, Castillo-Michel, Hiram, Omaña-Sanz, Brenda, Hofmann, Annette, Vulpe, Christopher, Simonato, Jean-Pierre, Celle, Caroline, Charlet, Laurent, and Gilbert, Benjamin

Subjects
Animals, Cell Line, Cells, Cultured, Electric Conductivity, Endosomes, Fibroblasts, Fishes, Humans, Lysosomes, Mice, Nanowires, Oxidative Stress, Silver, nanotechnology, endocytosis, fiber toxicity
Abstract

Fibrous particles interact with cells and organisms in complex ways that can lead to cellular dysfunction, cell death, inflammation, and disease. The development of conductive transparent networks (CTNs) composed of metallic silver nanowires (AgNWs) for flexible touchscreen displays raises new possibilities for the intimate contact between novel fibers and human skin. Here, we report that a material property, nanowire-bending stiffness that is a function of diameter, controls the cytotoxicity of AgNWs to nonimmune cells from humans, mice, and fish without deterioration of critical CTN performance parameters: electrical conductivity and optical transparency. Both 30- and 90-nm-diameter AgNWs are readily internalized by cells, but thinner NWs are mechanically crumpled by the forces imposed during or after endocytosis, while thicker nanowires puncture the enclosing membrane and release silver ions and lysosomal contents to the cytoplasm, thereby initiating oxidative stress. This finding extends the fiber pathology paradigm and will enable the manufacture of safer products incorporating AgNWs.

Published
2019

2. Nerve Agent Sensors Sub-ppm Detection of Nerve Agents Using Chemically Functionalized Silicon Nanoribbon Field-Effect Transistors**

Author

Clavaguera, Simon, Carella, Alexandre, Caillier, Laurent, Celle, Caroline, Pécaut, Jacques, Lenfant, Stéphane, Vuillaume, Dominique, Simonato, Jean-Pierre, Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Nanosciences et Cryogénie (INAC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
nanotechnology, silicon nanoribbons, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, field-effect transistors, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], sensors, nerve agents
Abstract

International audience; Organophosphorus compounds (OPs) represent one of the most important and lethal classes of chemical warfare agents (e.g. sarin, tabun, soman). Highly active volatile OPs are powerful inhibitors of acetylcholinesterase, which is a critical enzyme of the nervous system. [1] The ease of manufacturing OPs based on inexpensive starting materials makes these agents a weapon of choice for terrorist attacks. [2] Thus, the rapid sensing of these nerve agents has recently become an increasingly important research goal. Various approaches have been reported for the detection of these chemical warfare agents including colorimetric and fluorimetric spec-troscopies, [3] enzymatic assays, [4] piezoelectric devices, [5] single-walled carbon nanotube resistors [6] and capacitors. [7] However, these systems are plagued by limitations such as slow response time, moderate selectivity, operational complexity , or limited portability. Field-effect transistors (FET) based on nanomaterials such as semiconducting nanowires, nanoribbons, or carbon nanotubes have been recently explored for chemical and biological detection. [8] Their high effectiveness is mainly ascribed to an extreme sensitivity to electrostatic changes at the surface of the semiconductor and/or modifications of the Schottky barrier at the semiconductor/metal interface. A charge generation in the vicinity of the semiconductor of a FET is known to alter the electrical properties of the device. [9]

Published
2010

3. Flexible transparent conductive materials based on silver nanowire networks: a review.

Author

Langley, Daniel, Giusti, Gaël, Mayousse, Céline, Celle, Caroline, Bellet, Daniel, and Simonato, Jean-Pierre

Subjects
THERMAL conductivity, NANOWIRES, THERMAL properties, THERMAL conductivity measurement, NANOSTRUCTURED materials, NANOTECHNOLOGY
Abstract

The class of materials combining high electrical or thermal conductivity, optical transparency and flexibility is crucial for the development of many future electronic and optoelectronic devices. Silver nanowire networks show very promising results and represent a viable alternative to the commonly used, scarce and brittle indium tin oxide. The science and technology research of such networks are reviewed to provide a better understanding of the physical and chemical properties of this nanowire-based material while opening attractive new applications. [ABSTRACT FROM AUTHOR]

Published
2013
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