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Your search keyword '"Belokon YN"' showing total 2 results
Start Over Author "Belokon YN" Topic naphthols
2 results on '"Belokon YN"'

1. Using the same organocatalyst for asymmetric synthesis of both enantiomers of glutamic acid-derived Ni(II) complexes via 1,4-additions of achiral glycine and dehydroalanine Schiff base Ni(II) complexes.

Author

Belokon YN, Gugkaeva ZT, Hakobyan KV, Maleev VI, Moskalenko MA, Khrustalev VN, Saghyan AS, Tsaloev AT, and Babievsky KK

Subjects
1-Carboxyglutamic Acid chemistry, Alanine analogs & derivatives, Alanine chemistry, Catalysis, Glycine chemistry, Naphthols metabolism, Nickel chemistry, Stereoisomerism, Glutamic Acid chemistry, Naphthols chemistry, Schiff Bases chemistry
Abstract

(S)- and (R)-BIMBOL were efficient PT catalysts of asymmetric Michael addition of prochiral Ni-PBP-Gly (1) to acrylic esters and malonic esters to Ni-PBP-Δ-Ala (2) correspondingly. The salient feature of the catalysis is opposite configurations of Glu prepared via the two paths with BIMBOL of the same configuration and a perspective novel catalytic procedure for the synthesis of Gla derivatives.

Published
2012
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2. Catalytic enantioselective synthesis of 18F-fluorinated alpha-amino acids under phase-transfer conditions using (S)-NOBIN.

Author

Krasikova RN, Zaitsev VV, Ametamey SM, Kuznetsova OF, Fedorova OS, Mosevich IK, Belokon YN, Vyskocil S, Shatik SV, Nader M, and Schubiger PA

Subjects
Animals, Catalysis, Dihydroxyphenylalanine isolation & purification, Fluorine Radioisotopes chemistry, Fluorine Radioisotopes isolation & purification, Fluorine Radioisotopes pharmacokinetics, Glioma diagnostic imaging, Isomerism, Metabolic Clearance Rate, Organ Specificity, Phase Transition, Radionuclide Imaging, Radiopharmaceuticals chemical synthesis, Radiopharmaceuticals isolation & purification, Radiopharmaceuticals pharmacokinetics, Rats, Rats, Wistar, Tissue Distribution, Tyrosine isolation & purification, 2-Naphthylamine analogs & derivatives, 2-Naphthylamine chemistry, Dihydroxyphenylalanine analogs & derivatives, Dihydroxyphenylalanine chemistry, Dihydroxyphenylalanine pharmacokinetics, Glioma metabolism, Isotope Labeling methods, Naphthols chemistry, Tyrosine chemistry, Tyrosine pharmacokinetics
Abstract

We describe a new method for the asymmetric synthesis of [(18)F]fluorinated aromatic alpha-amino acids (FAA) under phase transfer conditions using achiral glycine derivative NiPBPGly and (S)-NOBIN as a novel substrate/catalyst pair. The key alkylation step proceeds under mild conditions. Substituted [(18)F]fluorobenzylbromides were prepared using nucleophilic [(18)F]fluoride and were used as alkylation agents. Two important FAA, 2-[(18)F]fluoro-L-tyrosine (2-FTYR) and 6-[(18)F]fluoro-L-3,4-dihydroxyphenylalanine (6-FDOPA), were synthesized with an ee of 92 and 96%, respectively. The total synthesis time was 110-120 min and radiochemical yields (d.c.) were 25+/-6% for 2-FTYR and 16+/-5% for 6-FDOPA.

Published
2004
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