1. Potentiated antibodies to mu-opiate receptors: effect on integrative activity of the brain.
- Author
-
Geiko VV, Vorob'eva TM, Berchenko OG, and Epstein OI
- Subjects
- Animals, Rats, Receptors, Opioid immunology, Seizures drug therapy, Antibodies pharmacology, Brain drug effects, Brain metabolism, Narcotic Antagonists, Self Stimulation drug effects
- Abstract
The effect of homeopathically potentiated antibodies to mu-receptors (10(-100) wt %) on integrative activity of rat brain was studied using the models of self-stimulation of the lateral hypothalamus and convulsions produced by electric current. Electric current was delivered through electrodes implanted into the ventromedial hypothalamus. Single treatment with potentiated antibodies to mu-receptors increased the rate of self-stimulation and decreased the threshold of convulsive seizures. Administration of these antibodies for 7 days led to further activation of the positive reinforcement system and decrease in seizure thresholds. Distilled water did not change the rate of self-stimulation and seizure threshold.
- Published
- 2003
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