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Introduction: FNAC has a pivotal role in the evaluation of breast lesions. Cytological grading systems are being utilized for the categorization of breast lesions. Modified Masood’s scoring System (MMSS) is used to improve the grading system for accurate pre-operative diagnosis. This study aims to assess the effectiveness and accuracy of the Modified Masood Scoring System for evaluating breast lesions and their correlation with histopathological diagnosis. Materials and Methods: This is a prospective study conducted in the Department of Pathology, MGM Medical College, Navi Mumbai which included 40 patients who presented with clinically palpable breast lump and were subjected to FNAC along with histopathological examination. The cytological smears were grouped into four categories according to MMSS. Correlation and concordance analysis between cytological categories and histopathological diagnosis was carried out. Observations and Results: The age of the patients ranged from 17 to 70 years with a mean age of 38.12 years, right-sided breast lesions were more common as compared to the left side. Of the total 40 cases, 27 cases were benign, and 13 cases were malignant on histopathology. The most common benign breast lesion was Fibroadenoma [Figure 1] and the malignant lesion was infiltrating duct carcinoma [Figure 2]. The sensitivity, specificity, Positive predictive value, Negative predictive value, and diagnostic accuracy were 76.9%, 100%, 100%, 90%, and 92.5% respectively. Conclusion: MMSS is simple, cost-effective, easily reproducible, reliable, and can be applied to FNAC aspirates to increase the diagnostic accuracy of Breast Lesions. [ABSTRACT FROM AUTHOR]

Background: FNAC is a simple, safe and cost-effective method and is one of the triple diagnostic triads along with clinical breast examination and radiology methods (mammography/ ultrasonography).Cytological diagnosis is very beneficial for the preoperative assessment of various breast lesions. The application of LBC technique along with conventional smear can strengthen the efficacy of diagnosing various breast lesions on FNAC. Aim: Comparison of liquid-based cytology versus conventional smears in fine needle aspiration cytology of breast lesions. Materials and Methods: A prospective study of 50 cases conducted over a period of 16 months included all female patients referred to the cytology department for FNAC. Two different passes were given, the first pass was used to prepare conventional smears and second pass was used for LBC smears. Results: Among 50 cases, 38 (76%) were benign and 12 (24%) were malignant. The commonest benign lesion was fibroadenoma and malignant lesion was Infiltrating Ductal Carcinoma. The difference between LBC and conventional smears was statistically significant pertaining to background blood debris (p < 0.00001), informative background (p = 0.0004) and cellular architecture (p = 0.0075) while it was not statistically significant for cellularity, mono layering, nuclear and cytoplasmic details The sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNAC in both LBC and conventional smears were similar, being 80%, 100%, 100%, 95.23% and 96% respectively. Conclusion: LBC cannot replace conventional cytology but can be used as a supplement with the conventional method to minimize false negative cytology rate and to increase the diagnostic accuracy of breast lesions. [ABSTRACT FROM AUTHOR]