1. Lack of carcinogenicity of 8-nitroquinoline on long-term in vivo test in hamsters.
- Author
-
Furukawa F, Kishimoto Y, Toyoda K, Satou H, Takahashi M, and Hayashi Y
- Subjects
- Administration, Oral, Animals, Body Weight drug effects, Cricetinae, Female, Male, Mesocricetus, Nitroquinolines administration & dosage, Time Factors, Neoplasms, Experimental chemically induced, Nitroquinolines toxicity
- Abstract
Syrian golden hamsters were administered 8-nitroquinoline, at a concentration of 0.05%, in a 10% ethanol solution as drinking water for 104 weeks. The animals were kept under observation until 112 weeks of age when the experiment was terminated. Both control and treated groups developed tumors in a pattern indistinguishable from that usually observed in Syrian golden hamsters. Thus the result of this experiment indicates that 8-nitroquinoline given orally at a concentration of 0.05% is not carcinogenic in Syrian golden hamsters.
- Published
- 1985
- Full Text
- View/download PDF