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1. Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34.

Author

Bartolini E, Van Moer K, and Janji B

Subjects
Animals, Humans, Mice, Autophagy drug effects, Class III Phosphatidylinositol 3-Kinases antagonists & inhibitors, Membrane Proteins agonists, Membrane Proteins metabolism, Neoplasms drug therapy, Neoplasms immunology, Neoplasms pathology
Abstract

We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists., Competing Interests: No potential conflict of interest was reported by the author(s)., (© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.)

Published
2024
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