1. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity.
- Author
-
Li Y, Chen W, Kang Y, Zhen X, Zhou Z, Liu C, Chen S, Huang X, Liu HJ, Koo S, Kong N, Ji X, Xie T, and Tao W
- Subjects
- Humans, Animals, Mice, Reactive Oxygen Species, Cell Line, Tumor, Ultrasonic Therapy, Carcinoma, Hepatocellular therapy, Triple Negative Breast Neoplasms therapy, Liver Neoplasms therapy, Neoplasms therapy, Nanoparticles therapeutic use
- Abstract
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC). SnSNPs possess a narrow bandgap (1.18 eV), allowing for efficient electron (e
- )-hole (h+ ) pair separation to generate reactive oxygen species under US activation. More importantly, SnSNPs display mild photothermal properties that can in situ denature tumor collagen and facilitate deep penetration into the tumor mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by SnSNPs and boosts antitumor immunity. In mouse models of malignant TNBC and hepatocellular carcinoma (HCC), the combination of robust SDT and enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. This study presents an innovative approach to enhance SDT and antitumor immunity using the denaturation-and-penetration strategy, offering a potential combined sono-immunotherapy approach for the cancer nanomedicine field., (© 2023. The Author(s).)- Published
- 2023
- Full Text
- View/download PDF