1. [Comparative clinical study of MF(mitomycin and 5-fluorouracil) and MF.BH-AC therapy].
- Author
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Satou H, Kamano T, Izumi T, and Yoshida M
- Subjects
- Adult, Aged, Clinical Trials as Topic, Colonic Neoplasms drug therapy, Cytarabine administration & dosage, Cytarabine analogs & derivatives, Female, Fluorouracil administration & dosage, Humans, Lung Neoplasms drug therapy, Male, Middle Aged, Mitomycins administration & dosage, Stomach Neoplasms drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Neoplasms drug therapy
- Abstract
Sunrabim for injection (BH-AC), one of the antitumor agents available for acute leukemia, has considerable activity against a variety of transplanted solid tumors in rats and mice. A comparative clinical study was performed by randomized controlled trial on two different combined chemotherapies of MMC, 5-FU (MF group), and MMC, 5-FU, BH-AC (MF . BH-AC group) for 64 patients with a variety of solid cancers. Among 64 patients, 47 were evaluable for response (MF group: 23/32, MF . BH-AC group: 24/32). The partial response rate of the MF group was 4.3% (1/23), and that of the MF . BH-AC group was 33.3% (8/24). MF . BH-AC therapy was found to be more effective than MF therapy. The toxicity rates of the two therapies were similar (MF group: 46.7%, MF . BH-AC group: 50.0%). This study suggests that combined chemotherapy of MF plus BH-AC is more effective on a variety of solid cancers in comparison to MF therapy.
- Published
- 1986