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A pandemic that is fast developing, the coronavirus epidemic is putting unprecedented pressure on healthcare systems. Children with renal disorders, including those undergoing renal transplantation, those with chronic kidney disease, and those with acute kidney damage necessitating dialysis, offer treatment issues due to COVID-19, particularly for those using long-term immunosuppressive medicines. The urgent requirement is for us to be ready to handle this vulnerable group of kids. This article's goals are to help caregivers and medical professionals manage children with renal illnesses, maintain patient well-being, and safeguard staff from infection. Setting:Participants and their data were drawn from an existing consent to contact database of the Infectious disease center of the Khorezm region. The candidates were 2 to 12 years of age, 20 women, and the ratio of male to female children was 67 % to 87 %. These individuals were receiving care (treatment and medication support) at different centers especially designated for Covid-19 infection in the Khorezm region and at different clinics in the Khorezm region. We retrieved the data from the infectious control center where all the data were collected from all centers of the Khorezm region. They can speak English or Russian, and agreed to be contacted for further research. Methods:A prospective study with Cohort study/guidelines from WHO for Covid-19 care and self-protection. A combined Cohort study of the COVID-19 survey was performed telephonically and personally for 15-20 minutes maximum, which included a discussion with doctors who attended and had any information about this syndrome. Research Focus:This researchis focusing ontheproblems of (MIS-C), which is a rare complication of COVID-19, but it can be serious or dangerous. The symptoms can overlap with infections and other illnesses. What are the circumstances and conditions of this disease, and what steps we can take to address them?