1. A role for the locus coeruleus in the modulation of feeding
- Author
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Natale R. Sciolino, Madeline Hsiang, Christopher M. Mazzone, Leslie R. Wilson, Nicholas W. Plummer, Jaisal Amin, Kathleen G. Smith, Christopher A. McGee, Sydney A. Fry, Cindy X. Yang, Jeanne M. Powell, Michael R. Bruchas, Alexxai V. Kravitz, Jesse D. Cushman, Michael J. Krashes, Guohong Cui, and Patricia Jensen
- Subjects
Noradrenergic neurons ,0303 health sciences ,Lateral hypothalamus ,Endogeny ,Optogenetics ,Biology ,Arousal ,03 medical and health sciences ,0302 clinical medicine ,Feeding behavior ,nervous system ,Locus coeruleus ,Neuroscience ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Recent data suggest that LC-NE neurons play a role in fear-induced suppression of feeding, but their endogenous activity in naturally behaving animals has not been explored. We found that endogenous activity of LC-NE neurons was enhanced during food approach and suppressed during food consumption, and that these food-evoked LC-NE responses were attenuated in sated mice. Interestingly, visual-evoked LC-NE activity was also attenuated in sated mice, demonstrating that internal satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by brief or longer durations of LC-NE activation. Lastly, we demonstrated that activation of LC neurons suppresses feeding and enhances avoidance and anxiety-like responding through a projection to the lateral hypothalamus. Collectively, our data suggest that LC-NE neurons modulate feeding by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g., nutritional state).
- Published
- 2019
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