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Your search keyword '"Serotonergic innervation"' showing total 3 results
Start Over Descriptor "Serotonergic innervation" Topic nervous system
3 results on '"Serotonergic innervation"'

1. Serotonergic modulation of the limbic system

Author

Hensler, Julie G.

Subjects
*LIMBIC system, *NEUROTRANSMITTERS, *NEURAL transmission, *NERVOUS system
Abstract

Abstract: The limbic system is composed of cortical as well as subcortical structures, which are intimately interconnected. The resulting macrostructure is responsible for the generation and expression of motivational and affective states. Especially high levels of serotonin are found in limbic forebrain structures. Serotonin projections to these structures, which arise from serotonergic cell body groups in the midbrain, form a dense plexus of axonal processes. In many areas of the limbic system, serotonergic neurotransmission can best be described as paracrine or volume transmission, and thus serotonin is believed to play a neuromodulatory role in the brain. Serotonergic projections to limbic structures, arising primarily from the dorsal and median raphe nuclei, compose two distinct serotonergic systems differing in their topographic organization, electrophysiological characteristics, morphology, as well as sensitivity to neurotoxins and perhaps psychoactive or therapeutic agents. These differences may be extremely important in understanding the role of these two serotonergic systems in normal brain function and in mental illness. Central serotonergic neurons or receptors are targets for a variety of therapeutic agents used in the treatment of disorders of the limbic system. [Copyright &y& Elsevier]

Published
2006
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2. The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual-probe microdialysis

Subjects
RELEASE, TRYPTOPHAN-HYDROXYLASE, locus coeruleus, dorsal raphe nucleus, microdialysis, SEROTONERGIC INNERVATION, FIRING ACTIVITY, scrotonin), BRAIN-STEM, RECEPTORS, AFFERENTS, nervous system, 5-HT (5-hydroxy-tryptamine, noradrenaline, TYROSINE-HYDROXYLASE ACTIVITY, NORADRENERGIC NEURONS, RAT
Abstract

The interaction between the locus coeruleus and dorsal raphe nucleus was investigated by means of dual-probe microdialysis in conscious rats. The release of noradrenaline and 5-hydroxytryptamine (5-HT) after inhibition or stimulation of locus cocruleus and dorsal raphe activity was sampled in both nuclei and analysed by high-pressure liquid chromatography (HPLC). The inhibition of locus coeruleus activity by the infusion of the alpha2-adrenoceptor agonist clonidine (100 muM) decreased the release of noradrenaline to 20% in the locus coeruleus and 30% in the dorsal raphe, whilst the release of 5-HT decreased to 80% of control in the two brain areas, The excitation of locus coeruleus activity by the muscarinic receptor agonist carbachol (100 muM) led to an increase in the release of noradrenaline to 240% and 220% of control in the locus coeruleus and dorsal raphe, respectively, The release of 5-HT in both nuclei did not respond to the carbachol infusion into the locus coeruleus. Infusion of the 5-HT1A receptor agonist flesinoxan into the dorsal raphe (1 muM) significantly decreased the release of 5-HT in the dorsal raphe and locus coeruleus to 45% and 65% of control, respectively. The release of noradrenaline was decreased in the dorsal raphe to 45% by flesinoxan, whereas no changes were seen in the release of noradrenaline in the locus coeruleus. In conclusion, the innervation of the dorsal raphe by the locus coeruleus has a slight excitatory effect on the release of 5-HT in the dorsal raphe. The dorsal raphe does not exert a direct inhibitory influence on the release of noradrenaline in the locus cocruleus. Finally, the release of noradrenaline in the dorsal raphe may be locally regulated by 5-HT1A receptors. (C) 2002 Published by Elsevier Science B.V.

Published
2002

3. The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual-probe microdialysis

Author

Pudovkina, OL, Cremers, TIFH, Westerink, BHC, Biomonitoring and Sensoring, and Medicinal Chemistry and Bioanalysis (MCB)

Subjects
RELEASE, TRYPTOPHAN-HYDROXYLASE, locus coeruleus, dorsal raphe nucleus, microdialysis, SEROTONERGIC INNERVATION, FIRING ACTIVITY, BRAIN-STEM, RECEPTORS, AFFERENTS, nervous system, noradrenaline, TYROSINE-HYDROXYLASE ACTIVITY, NORADRENERGIC NEURONS, RAT, 5-HT (5-hydroxy-tryptamine, scrotonin)
Abstract

The interaction between the locus coeruleus and dorsal raphe nucleus was investigated by means of dual-probe microdialysis in conscious rats. The release of noradrenaline and 5-hydroxytryptamine (5-HT) after inhibition or stimulation of locus cocruleus and dorsal raphe activity was sampled in both nuclei and analysed by high-pressure liquid chromatography (HPLC). The inhibition of locus coeruleus activity by the infusion of the alpha2-adrenoceptor agonist clonidine (100 muM) decreased the release of noradrenaline to 20% in the locus coeruleus and 30% in the dorsal raphe, whilst the release of 5-HT decreased to 80% of control in the two brain areas, The excitation of locus coeruleus activity by the muscarinic receptor agonist carbachol (100 muM) led to an increase in the release of noradrenaline to 240% and 220% of control in the locus coeruleus and dorsal raphe, respectively, The release of 5-HT in both nuclei did not respond to the carbachol infusion into the locus coeruleus. Infusion of the 5-HT1A receptor agonist flesinoxan into the dorsal raphe (1 muM) significantly decreased the release of 5-HT in the dorsal raphe and locus coeruleus to 45% and 65% of control, respectively. The release of noradrenaline was decreased in the dorsal raphe to 45% by flesinoxan, whereas no changes were seen in the release of noradrenaline in the locus coeruleus. In conclusion, the innervation of the dorsal raphe by the locus coeruleus has a slight excitatory effect on the release of 5-HT in the dorsal raphe. The dorsal raphe does not exert a direct inhibitory influence on the release of noradrenaline in the locus cocruleus. Finally, the release of noradrenaline in the dorsal raphe may be locally regulated by 5-HT1A receptors. (C) 2002 Published by Elsevier Science B.V.

Published
2002

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