1. Cerebrospinal fluid beta-2-microglobulin in HIV-1 infection, as a marker of neurological involvement.
- Author
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Perrella O, Carrieri PB, Izzo E, Marotta A, Liberti A, Soscia M, and Buscaino GA
- Subjects
- Acquired Immunodeficiency Syndrome blood, Acquired Immunodeficiency Syndrome complications, Adult, Biomarkers blood, Biomarkers cerebrospinal fluid, Female, Humans, Male, Nervous System Diseases complications, beta 2-Microglobulin metabolism, Acquired Immunodeficiency Syndrome cerebrospinal fluid, HIV-1, Nervous System Diseases cerebrospinal fluid, beta 2-Microglobulin cerebrospinal fluid
- Abstract
Cerebrospinal fluid (CSF) and serum concentration of beta-2-microglobulin (beta-2-m) were evaluated in 30 patients in various stages of HIV-1 infection. CSF beta-2-m and CSF/serum ratio were significantly higher in patients with neurological complications respect to asymptomatic subjects. These findings indicate that CSF beta-2-m and CSF/serum ratio may be a useful marker of neurological involvement in HIV-1 infection.
- Published
- 1991
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