1. Neural precursor cells tune striatal connectivity through the release of IGFBPL1.
- Author
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Butti E, Cattaneo S, Bacigaluppi M, Cambiaghi M, Scotti GM, Brambilla E, Ruffini F, Sferruzza G, Ripamonti M, Simeoni F, Cacciaguerra L, Zanghì A, Quattrini A, Fesce R, Panina-Bordignon P, Giannese F, Cittaro D, Kuhlmann T, D'Adamo P, Rocca MA, Taverna S, and Martino G
- Subjects
- Animals, Humans, Mice, Cardiac Electrophysiology, Insulin-Like Growth Factor Binding Proteins physiology, Neural Stem Cells physiology, Tumor Suppressor Proteins physiology, Lateral Ventricles physiology
- Abstract
The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity., (© 2022. The Author(s).)
- Published
- 2022
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