8 results on '"Harrison, Tondi"'
Search Results
2. Inflammatory mediators of stress exposure and neurodevelopment in very preterm infants: Protocol for the stress neuro‐immune study.
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Nist, Marliese Dion, Pickler, Rita H., Steward, Deborah K., Harrison, Tondi M., and Shoben, Abigail B.
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CHRONIC diseases ,CYTOKINES ,INFANT development ,INFLAMMATORY mediators ,NEUROPHYSIOLOGY ,SCIENTIFIC observation ,PSYCHOLOGICAL stress ,REPEATED measures design ,CHILDREN - Abstract
Copyright of Journal of Advanced Nursing (John Wiley & Sons, Inc.) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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3. Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease.
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Harrison, Tondi M., Chen, Chao-Ying, Stein, Phyllis, Brown, Roger, and Heathcock, Jill C.
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AUTONOMIC nervous system physiology , *AUTONOMIC nervous system diseases , *CONGENITAL heart disease , *DEVELOPMENTAL disabilities , *ELECTROCARDIOGRAPHY , *HEART beat , *NEONATAL intensive care , *PARADIGMS (Social sciences) , *PARENT-infant relationships , *POSTNATAL care , *PSYCHOLOGICAL tests , *RESEARCH , *RESEARCH funding , *STATISTICAL sampling , *NEONATAL intensive care units , *DESCRIPTIVE statistics , *KRUSKAL-Wallis Test , *DIAGNOSIS - Abstract
Background: Infants with complex congenital heart disease (CCHD) often develop neurodevelopmental disabilities. Cognitive abilities are associated with vagally mediated autonomic function. Skin-to-skin contact (SSC) interventions enhance infant neurodevelopment and autonomic function in other high-risk populations. Aim: To examine the effects of a neonatal SSC intervention on learning and autonomic function in 3-month-old infants: infants with CCHD who received neonatal SSC (n = 10), typically developing (TD) infants (n = 16), and infants with CCHD without SSC (n = 10). Methods: This secondary data analysis measured cognitive function using the mobile paradigm (MP), a classic measure of learning based on operant conditioning. Autonomic function was assessed with heart rate (HR) and HR variability (HRV). Data were analyzed with repeated-measures general linear mixed modeling with α =.10 for this exploratory study. Results: Learning rates were TD = 75%, cardiac-SSC = 70%, and cardiac-control = 40%. Learners demonstrated significant reductions in HRV during the MP; nonlearners exhibited no change. TD and cardiac-SSC groups exhibited increases in HR and reductions in HRV during the MP. No significant changes occurred in the cardiac-control group. Nonlinear HRV during the MP differed only in the TD group. Conclusions: Findings suggest improvements in cognitive and autonomic development in 3-month-old infants with CCHD who received neonatal SSC. Learning and autonomic function results in infants with CCHD who had not received SSC suggest reduced capacity to muster the physiologic resources to carry out this cognitive task. Findings provide preliminary evidence in support of implementation of SSC with infants with CCHD and support additional research. [ABSTRACT FROM AUTHOR]
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- 2019
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4. The biological embedding of neonatal stress exposure: A conceptual model describing the mechanisms of stress‐induced neurodevelopmental impairment in preterm infants.
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Nist, Marliese Dion, Harrison, Tondi M., and Steward, Deborah K.
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RISK factors of neurodegeneration ,CHILD development deviations -- Risk factors ,AUTONOMIC nervous system diseases ,CONCEPTUAL structures ,GENE expression ,IMMUNOLOGIC diseases ,PREMATURE infants ,PSYCHOLOGICAL stress ,CHILDREN - Abstract
The biological embedding of early life stress exposure may result in life‐long neurodevelopmental impairment in preterm infants. Infants hospitalized in the neonatal intensive care unit are exposed to significant experiential, environmental, and physiologic stressors over the course of their extended hospitalization. Stress exposure during the sensitive period of brain development may alter biological processes, including functioning of the immune system, the autonomic nervous system, and the hypothalamic‐pituitary‐adrenal axis as well as gene expression. These alterations may subsequently affect brain structure and function. Changes to these processes may mediate the relationship between neonatal stress exposure and neurodevelopment in preterm infants and represent potential therapeutic targets to improve long‐term outcomes. The purpose of this paper is to introduce a conceptual model, based on published research, that describes the mechanisms mediating stress exposure and neurodevelopment impairment in preterm infants and to provide the theoretical foundation on which to base future descriptive research, intervention studies, and clinical care. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization.
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Weber, Ashley, Harrison, Tondi M., Sinnott, Loraine, Shoben, Abigail, and Steward, Deborah
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APGAR score , *BIOMARKERS , *LOW birth weight , *HOSPITAL care of newborn infants , *PREMATURE infants , *NEONATAL intensive care , *OXYTOCIN , *RESEARCH funding , *STATISTICAL sampling , *STATISTICAL power analysis , *STRUCTURAL equation modeling , *NEONATAL intensive care units , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. However, no studies have measured OT in the plasma and urine of premature infants. The purposes of this study were to describe plasma and urine OT levels of premature infants through 34 weeks corrected gestational age (CGA), determine whether plasma and urine OT are correlated, and explore associations between infant demographics and OT trajectories. Plasma and urine from 37 premature infants, born at gestational ages 25-28 6/7 weeks, were longitudinally collected at 14 days of life, then weekly until 34 weeks CGA. Plasma OT decreased with age, at a rate of 15% per week, and exhibited strong stability within infants. Urine OT was not correlated with plasma OT and did not show a significant trend over time; thus, urine may not be a reliable, noninvasive measurement in this population. Apgar score was the only infant demographic characteristic associated with plasma OT. Given the novelty of this work, replication is needed to confirm these findings, and future research should explore potential mechanisms (e.g., stress, normal maturation, and social experiences) that contribute to declining plasma OT levels in premature infants. [ABSTRACT FROM AUTHOR]
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- 2017
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6. Oxytocin trajectories and social engagement in extremely premature infants during NICU hospitalization.
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Weber, Ashley, Harrison, Tondi M., Steward, Deborah, Sinnott, Loraine, and Shoben, Abigail
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SOCIOEMOTIONAL selectivity theory , *INTERPERSONAL relations , *OXYTOCIN , *NEURAL development , *HOSPITAL care of children , *CHILD development , *GESTATIONAL age , *HOSPITAL care , *PREMATURE infants , *MOTHERHOOD , *PSYCHOLOGY of mothers , *NEONATAL intensive care , *PARENT-child relationships , *PARENTING , *RESEARCH funding , *SOCIAL skills , *PSYCHOLOGICAL stress , *NEONATAL intensive care units , *PSYCHOLOGY - Abstract
Extremely premature infants, born 28 weeks gestation or less, are at high risk for impaired socioemotional development, due in part to exposure to early stressful social experiences that alter brain development. Understanding mediators that link experience with outcomes is necessary to assess premature infant responses to social experiences that are critical to brain development. The hormone oxytocin (OT), released during supportive interactions, has potential as a biomarker of the premature infant's responses to social experiences. The purpose of this study was to examine associations among infant plasma OT trajectories and maternal-infant social engagement behaviors during initial hospitalization. This study also examined demographic correlates of engagement behaviors in mothers and infants. Plasma from 28 extremely premature infants, born gestational ages 25-28 6/7 weeks, was collected at 14 days of life, then weekly until 34 weeks. Social engagement behaviors were measured by the Parent-Child Early Relational Assessment during a videotaped feeding when the infant was receiving one-quarter full oral feeds. Maternal-infant demographics were extracted from the medical record. Higher infant plasma OT was associated with lower infant social engagement, but no associations were found with maternal social engagement. Infant social engagement was positively related to maternal social engagement. Maternal parity was related to maternal social engagement, and infant demographics did not predict infant social engagement. The significant, yet negative, association between infant OT and engagement provides support for the measurement of OT as a neurobiological antecedent to infant social behaviors. Finally, this research suggests that during the earliest period of infant socio-behavioral development, premature infants are behaviorally reactive to the social engagement behaviors of their mothers. [ABSTRACT FROM AUTHOR]
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- 2017
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7. Schore’s Regulation Theory: Maternal–Infant Interaction in the NICU as a Mechanism for Reducing the Effects of Allostatic Load on Neurodevelopment in Premature Infants.
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Weber, Ashley M., Harrison, Tondi M., and Steward, Deborah K.
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PHYSIOLOGICAL adaptation , *PREMATURE infants , *INFANT development , *MOTHER-child relationship , *MOTHERHOOD , *NEONATAL intensive care , *NERVOUS system , *NEUROBIOLOGY , *PARENTING , *PSYCHOLOGICAL stress , *THEORY , *NEONATAL intensive care units - Abstract
Premature infants confront numerous physiologic and environmental stressors in the neonatal intensive care unit (NICU) that have the potential to permanently alter their neurodevelopment. Schore’s regulation theory postulates that positive maternal–infant interactions can shape the infant’s developmental outcomes through inducing mechanistic changes in brain structure and function. The purposes of this article are to explain the regulation of infant neurobiological processes during interactions between mothers and healthy infants in the context of Schore’s theory, to identify threats to these processes for premature infants, and to propose principles of clinical practice and areas of research necessary to establish a supportive environment and prevent or reduce maladaptive consequences for these vulnerable infants. A premature birth results in the disruption of neurodevelopment at a critical time. Chronic exposure to stressors related to the NICU environment overwhelms immature physiologic and stress systems, resulting in significant allostatic load, as measured by long-term neurodevelopmental impairments in the premature infant. Positive maternal–infant interactions during NICU hospitalization and beyond have the potential to reduce neurologic deficits and maximize positive neurodevelopmental outcomes in premature infants. The quality of the maternal–infant interaction is affected not only by the infant’s developing neurobiology but also by the mother’s responses to the stressors surrounding a premature birth and mothering an infant in the NICU environment. Nurses can empower mothers to overcome these stressors, promote sensitive interactions with their infants, and facilitate neurodevelopment. Research is critically needed to develop and test nursing interventions directed at assisting mothers in supporting optimal neurodevelopment for their infants. [ABSTRACT FROM PUBLISHER]
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- 2012
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8. Inflammatory predictors of neurobehavior in very preterm infants.
- Author
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Nist, Marliese Dion, Pickler, Rita H., Harrison, Tondi M., Steward, Deborah K., and Shoben, Abigail B.
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PREMATURE infants , *TUMOR necrosis factors , *CHORIOAMNIONITIS , *INTERLEUKIN-1 receptors , *INTERLEUKIN-6 , *PREMATURE labor , *CYTOKINES , *DEVELOPMENTAL disabilities , *PSYCHOSOCIAL factors , *INFANT psychology - Abstract
Background: Preterm infants are at risk for impaired neurodevelopment. Inflammation may be an important modifiable mediator of preterm birth and neurodevelopmental impairment, but few studies have examined longitudinal measures of inflammation.Objective: To determine the relationship between longitudinal measures of inflammation and neurobehavior in very preterm infants.Study Design: Non-experimental, repeated measures cohort study.Methods: Very preterm infants were enrolled between October 2017 and December 2018. Blood was collected weekly until 35 weeks post-menstrual age for the quantification of plasma cytokines. Neurobehavior was assessed at 35 weeks post-menstrual age using the cluster scores for motor development and vigor and alertness/orientation from the Neurobehavioral Assessment of the Preterm Infant. Multiple linear regression models with robust standard errors were used to analyze the data. Average levels of individual cytokines, cytokine trends, and composite scores were used as measures of inflammation.Results: Seventy-three infants were enrolled in the study. Interleukin-1 receptor antagonist was associated with motor development and vigor scores. Interleukin-6 was associated with alertness/orientation scores. Tumor necrosis factor-alpha and composite scores of inflammation were associated with motor development and vigor and alertness/orientation scores. There were interactions with post-menstrual age at birth and infant sex.Conclusion: Inflammation may be an important predictor of short-term neurobehavior in preterm infants. Interleukin-1 receptor antagonist, interleukin-6, and tumor necrosis factor-alpha are key cytokines for studies of preterm infants, but composite scores may be a better measure of inflammation than individual cytokines. Inflammation can be damaging to the immature brain and may be a specific target for future interventions to improve outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2020
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