1. Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease
- Author
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Kremer, Thomas, Taylor, Kirsten I, Siebourg‐Polster, Juliane, Gerken, Thomas, Staempfli, Andreas, Czech, Christian, Dukart, Juergen, Galasko, Douglas, Foroud, Tatiana, Chahine, Lana M, Coffey, Christopher S, Simuni, Tanya, Weintraub, Daniel, Seibyl, John, Poston, Kathleen L, Toga, Arthur W, Tanner, Caroline M, Marek, Kenneth, Hutten, Samantha J, Dziadek, Sebastian, Trenkwalder, Claudia, Pagano, Gennaro, and Mollenhauer, Brit
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Neurosciences ,Brain Disorders ,Parkinson's Disease ,Clinical Research ,Neurodegenerative ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,3 ,4-Dihydroxyphenylacetic Acid ,Homovanillic Acid ,Humans ,Levodopa ,Neurotransmitter Agents ,Parkinson Disease ,monoamine metabolites ,catecholamine ,neurotransmitter ,biomarker ,Parkinson&apos ,s disease ,CSF ,homovanillic acid ,Parkinson's disease ,Clinical Sciences ,Human Movement and Sports Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundCerebrospinal fluid (CSF) levels of monoamine metabolites may represent biomarkers of Parkinson's disease (PD).ObjectiveThe aim of this study was quantification of multiple metabolites in CSF from PD versus healthy control subjects (HCs), including longitudinal analysis.MethodsAbsolute levels of multiple monoamine metabolites in CSF were quantified by liquid chromatography coupled with tandem mass spectrometry from 161 individuals with early PD and 115 HCs from the Parkinson's Progression Marker Initiative and de novo PD (DeNoPA) studies.ResultsBaseline levels of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were lower in individuals with PD compared with HCs. HVA levels correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale total scores (P
- Published
- 2021