1. Excitatory Deep Repetitive Transcranial Magnetic Stimulation With H-coil as Add-on Treatment of Motor Symptoms in Parkinson's Disease: An Open Label, Pilot Study
- Author
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Abraham Zangen, Giancarlo Comi, L. Ferrari, Letizia Leocani, E. Coppi, M. Fichera, S. Velikova, Arturo Nuara, M. Bianco, D. Dalla Libera, Elise Houdayer, G. Di Maggio, L. Straffi, Raffaella Chieffo, Francesca Spagnolo, Maria Antonietta Volontè, Spagnolo, F, Volonté, Ma, Fichera, M, Chieffo, R, Houdayer, E, Bianco, M, Coppi, E, Nuara, A, Straffi, L, Di Maggio, G, Ferrari, L, Dalla Libera, D, Velikova, S, Comi, Giancarlo, Zangen, A, and Leocani, ANNUNZIATA MARIA LETIZIA
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,medicine.medical_treatment ,Repetitive transcranial magnetic stimulation ,Biophysics ,Pilot Projects ,Motor symptoms ,lcsh:RC321-571 ,Physical medicine and rehabilitation ,medicine ,Humans ,Deep transcranial magnetic stimulation ,Adverse effect ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Aged ,H-coil ,General Neuroscience ,Motor Cortex ,Parkinson Disease ,Middle Aged ,medicine.disease ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,Treatment Outcome ,Add on treatment ,Research Design ,Physical therapy ,Excitatory postsynaptic potential ,Female ,Neurology (clinical) ,Open label ,Psychology - Abstract
Background Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a potential treatment for Parkinson's disease (PD). H-coils, inducing deeper and wider magnetic fields compared to traditional coils, may be potentially useful in PD, characterized by widespread, bilateral involvement of cortico-subcortical circuits. Objective To evaluate the safety of repetitive deep TMS (rDTMS) with H-coil as add-on treatment of motor symptoms in PD. Methods Twenty-seven PD patients (aged 60.1 ± 6.8 y; PD-duration: 6.3 ± 2.8 y; motor-UPDRS: 39.6 ± 10.1) underwent 12 rDTMS sessions over 4 weeks at excitatory (10 Hz) frequency over primary motor (M1) and bilateral prefrontal (PF) regions. Motor UPDRS off therapy was assessed before and after the last rDTMS session, together with safety records at each treatment session. Results No drop-outs or adverse events were recorded. Motor UPDRS significantly improved after rDTMS (10.8 points average reduction; P Conclusions High-frequency rDTMS might be a safe treatment for PD motor symptoms. Further placebo-controlled, randomized studies are warranted.
- Published
- 2014