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Abstract: Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-d-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species. [ABSTRACT FROM AUTHOR]

The article presents an abstract of the paper "Mechanisms of ADNF Peptide Protection Against Oxidative and Excitotoxic Neuronal Death," which will be presented at the 30th annual meeting of the American Society for Neurochemistry to be held from March 14-17, 1999 in New Orleans, Louisiana. The paper discusses how 9 amino acid fragment of activity-dependent neurotrophic factor peptide protects rat hippocampal neurons from oxidative injury and neuronal apoptosis.