1. Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review
- Author
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Zhou Zhu, Jia-Hong Lu, Min Li, Jia Liu, Zi-Ying Wang, Gang Chen, Ashok Iyaswamy, Ju-Xian Song, Cheng-Fu Su, and Sravan Gopalkrishnashetty Sreenivasmurthy
- Subjects
0301 basic medicine ,Autophagy-Related Proteins ,Traditional Chinese medicine ,Disease ,RM1-950 ,Neurodegenerative disease ,Neuroprotection ,03 medical and health sciences ,0302 clinical medicine ,Autophagy ,Medicine ,Animals ,Humans ,Medicine, Chinese Traditional ,Beneficial effects ,Pharmacology ,Neurons ,Mechanism (biology) ,business.industry ,Neurodegeneration ,Neurodegenerative Diseases ,General Medicine ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Nerve Degeneration ,Therapeutics. Pharmacology ,business ,Neuroscience ,Drugs, Chinese Herbal - Abstract
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
- Published
- 2021