1. Cytotoxic and neuroprotective activities of constituents from Alternaria alternate, a fungal endophyte of Psidium littorale.
- Author
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Xu J, Hu YW, Qu W, Chen MH, Zhou LS, Bi QR, Luo JG, Liu WY, Feng F, and Zhang J
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Biological Products chemistry, Biological Products isolation & purification, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Neuroprotective Agents chemistry, Neuroprotective Agents isolation & purification, Psidium microbiology, Alternaria chemistry, Antineoplastic Agents pharmacology, Biological Products pharmacology, Endophytes chemistry, Neuroprotective Agents pharmacology
- Abstract
Chemical investigation of the EtOAc extract of the plant-associated fungus Alternaria alternate in rice culture led to the isolation of a novel liphatic polyketone, alternin A (1), a new indole alkaloid (8), and a new sesquiterpene (11), together with 12 known compounds. Their structures were elucidated by the interpretation of extensive spectroscopic data, and the absolute configurations of 1-3 were established using calculations of ECD spectra, NMR data, and optical rotation values. Compound 1 possesses an unprecedented C25 liphatic polyketone skeleton. Compounds 5 and 10 exhibited potential cytotoxic activities against MCF-7 and HepG cells, and compounds 2, 7, and 9 exhibited potential neuroprotective activities in glutamate induced-PC12 injured cells., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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