1. Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis
- Author
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Kolahi, Sousan, Ghorbanihaghjo, Amir, Alizadeh, Samira, Rashtchizadeh, Nadereh, Argani, Hassan, Khabazzi, Ali-Reza, Hajialilo, Mehrzad, and Bahreini, Elham
- Subjects
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FISH oils , *DIETARY supplements , *NF-kappa B , *LIGANDS (Biochemistry) , *RHEUMATOID arthritis , *TUMOR necrosis factors , *STATISTICAL correlation , *PATIENTS - Abstract
Abstract: Objective : Soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) to osteoprotegerin ratio is designated as a bone metabolism equation in many rheumatologic disorders and would be modified with fish oil (FO) supplementation. Design and methods : Eighty-three females with rheumatoid arthritis were divided randomly to 40 and 43 patients treated with (1 g/day) or without FO for 3 months accompanied with conventional drugs, respectively. Osteoprotegerin, sRANKL, tumor necrosis factor alpha (TNFα) serum levels were measured before and after treatment. Results : Serum levels of osteoprotegerin increased, although sRANKL, TNFα and sRANKL/osteoprotegerin ratio decreased with FO therapy. A significant positive correlation was observed between sRANKL/osteoprotegerin ratio and TNFα levels (r =0.327, p =0.040) in the FO-treated group. Conclusions : FO could decrease the inflammatory response by lowering of serum TNFα levels and sRANKL/osteoprotegerin ratio. [Copyright &y& Elsevier]
- Published
- 2010
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