1. Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria
- Author
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Abdurrahman Elfulaty Ahmad, Adamu Girei Bakari, Bolanle Olufunke Priscilla Musa, Shettima Kagu Mustapha, Bello Yusuf Jamoh, Idris Nasir Abdullahi, Mohammed Ibrahim Tahir, Abdulqadri Olarenwaju Olatunji, Sumayya Hamza Maishanu, Ahmed Babangida Suleiman, Afolaranmi Tolulope, Claudia Hawkins, Atiene Solomon Sagay, Ayuba Zoakah, and Adebola Tolulope Olayinka
- Subjects
genotypes ,hepatitis b virus ,mixed-infection ,nigeria ,zaria ,Medicine - Abstract
Background: Hepatitis B virus (HBV) is hyperendemic in Nigeria. Available literature reveal genotype E as being predominant in West Africa. This study aimed at identifying the current pattern and prevalent genotypes of HBV in Zaria, Nigeria. Materials and Methods: Four millilitre of blood was collected in ethylenediaminetetraacetic acid-container from each of 165 HBV surface antigen-positive participants recruited purposively from the gastroenterology clinic from May to August, 2017. Plasma was separated and frozen at −20°C till analysis. Multiplex-nested polymerase chain reaction using type-specific primers was used to identify the various HBV genotypes. Results: Median (and interquartile range) age of the participants was 31.0 (25.5–39.0) years, with males constituting 107 (64.8%). Majority (83.6%) of the samples analysed were HBV-DNA-positive with 82.6% of the HBV-DNA-positive samples being mixed genotype infections. Irrespective of mode of occurrence, five HBV genotypes were identified with HBV/E (97.1%) being the most predominant, followed by HBV/B (82.6%), HBV/A (24.6%), then HBV/C (17.4%), while HBV/D (0.7%) was the least prevalent. Conclusion: In most (99.1%) of the mixed-infection were a combination of genotype E, the predominant genotype, with other genotypes predominantly genotype B. HBV genotypes E, B, A, C and D are the prevalent genotypes in Zaria, Nigeria, as they occur in single genotype and in mixed-genotypes pattern.
- Published
- 2019
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