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The prevalence of typhoid fever, malaria and schistosomiasis among 268 symptomatic patients in Edo State, Nigeria, was investigated. Blood, urine and stool samples were collected from 268 patients (163 males and 105 females). The results showed that of the total number examined, 65 (39.9%) males and 39 (37.1%) females had schistosome eggs in their urine. Ninety-five (58.3%) males and 67 (63.8%) females were infected with Salmonella typhi, while 88 (54.0%) males and 54 (51.4%) females had malaria parasites. Dual infections of schistosomiasis and typhoid fever were higher in females (17.14%) than males (16.6%). Thirty-three (20.3%) males and 24 (22.86%) females had both schistosomiasis and malaria. Typhoid fever and malaria occurred in 53 (32.5%) and 35 (33.3%) males and females, respectively. Triple infections with typhoid fever, malaria and schistosomiasis occurred among 16 (9.8%) males and 13 (12.4%) females. For all cases, children were more frequently infected than adults. This study provide insight into problems and complications in tropical diseases as dual or triple infections could occur concurrently in a patient.