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5 results on '"Blanco Fabiana"'

1. Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization.

Author

López GV, Blanco F, Hernández P, Ferreira A, Piro OE, Batthyány C, González M, Rubbo H, and Cerecetto H

Subjects
Animals, Antioxidants chemical synthesis, Antioxidants chemistry, Aorta, Thoracic drug effects, Cell Proliferation drug effects, Macrophages drug effects, Mice, Molecular Structure, Nitric Oxide Donors chemical synthesis, Nitric Oxide Donors chemistry, Oxadiazoles chemistry, Oxadiazoles pharmacology, Rats, Rats, Inbred WKY, Vasodilation drug effects, Vasodilator Agents chemical synthesis, Vasodilator Agents chemistry, X-Ray Diffraction, alpha-Tocopherol chemistry, alpha-Tocopherol pharmacology, Antioxidants pharmacology, Nitric Oxide metabolism, Nitric Oxide Donors pharmacology, Oxadiazoles chemical synthesis, Vasodilator Agents pharmacology, alpha-Tocopherol chemical synthesis
Abstract

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Published
2007
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2. Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs.

Author

López GV, Batthyány C, Blanco F, Botti H, Trostchansky A, Migliaro E, Radi R, González M, Cerecetto H, and Rubbo H

Subjects
Animals, Antioxidants chemical synthesis, Antioxidants chemistry, Antioxidants pharmacology, Humans, In Vitro Techniques, Magnetic Resonance Spectroscopy, Nitric Oxide Donors chemistry, Rats, Rats, Wistar, Spectrophotometry, Infrared, Tocopherols chemistry, Vasodilator Agents chemical synthesis, Vasodilator Agents chemistry, Vasodilator Agents pharmacology, Atherosclerosis prevention & control, Nitric Oxide chemistry, Nitric Oxide Donors chemical synthesis, Nitric Oxide Donors pharmacology, Tocopherols chemical synthesis, Tocopherols pharmacology
Abstract

Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.

Published
2005
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3. Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Author

Paola Hernández, Fabiana Blanco, Hugo Cerecetto, Oscar E. Piro, Mercedes González, Homero Rubbo, Gloria V. López, Ana M. Ferreira, Carlos Batthyány, López Gloria V., Blanco Fabiana, Hernández Paola, Ferreira Ana, Piro Oscar E., Batthyány Carlos, González Mercedes, Rubbo Homero, and Cerecetto Hugo

Subjects
Stereochemistry, Vasodilator Agents, alpha-Tocopherol, Clinical Biochemistry, Pharmaceutical Science, Aorta, Thoracic, Nitric Oxide, Rats, Inbred WKY, Biochemistry, Chemical synthesis, Antioxidants, Nitric oxide, Mice, chemistry.chemical_compound, X-Ray Diffraction, Drug Discovery, Animals, Vitamin E, Nitric Oxide Donors, Phenols, Tocopherol, Molecular Biology, Cell Proliferation, Oxadiazoles, Molecular Structure, Macrophages, Organic Chemistry, Furoxan, Biological activity, Combinatorial chemistry, In vitro, Rats, Vasodilation, chemistry, Molecular Medicine, NO donor, Antioxidant, LDL oxidation
Abstract

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Published
2007

4. 6-Methylnitroarachidonate: a novel esterified nitroalkene that potently inhibits platelet aggregation and exerts cGMP-mediated vascular relaxation

Author

Andrés Trostchansky, Hugo Cerecetto, Mercedes González, Fabiana Blanco, Lucía Bonilla, Gloria V. López, Homero Rubbo, Ana M. Ferreira, Blanco Fabiana, M Ferreira Ana, López Gloria V, Bonilla Lucía, González Mercedes, Cerecetto Hugo, Trostchansky Andrés, and Rubbo Homero

Subjects
Male, IBMX, Stereochemistry, Methylnitroarachidonate, Vasodilator Agents, Aorta, Thoracic, Arachidonic Acids, Lipid nitration, In Vitro Techniques, Nitroalkene, Nitric Oxide, Biochemistry, Rats, Inbred WKY, Muscle, Smooth, Vascular, Nitric oxide, chemistry.chemical_compound, Physiology (medical), Nitration, Animals, Humans, Nitric Oxide Donors, Fragmentation (cell biology), Sodium nitrite, Cyclic GMP, Inflammation, Nitaroarachidonic acid, Vasorelaxation, Rats, cGMP, Vasodilation, chemistry, Nitro, Endothelium, Vascular, Nitro-fatty acids, Platelet Aggregation Inhibitors, Methyl group
Abstract

Nitro-fatty acids represent endogenously occurring products of oxidant-induced nitration reactions. We have previously synthesized a mixture of four isomers of nitroarachidonic acid, a novel anti-inflammatory signaling mediator. In this study, we synthesized and chemically and biologically characterized for the first time an esterified nitroalkene derived from the nitration of methylarachidonate (AAMet): 6-methylnitroarachidonate (6-AAMetNO 2 ). Synthesis was performed by reacting AAMet with sodium nitrite under acidic conditions. Analysis by mass spectrometry (positive-ion ESI-MS) showed an [M + H] + ion of m/z 364, characteristic of AAMetNO 2 . Fragmentation of this ion yielded a daughter ion at m/z 317, corresponding to the neutral loss of the nitro group ([M + H − HNO 2 ] + ). Furthermore, IR signal at 1378 cm − 1 and NMR data confirmed the structure of a 6-nitro-positional isomer. This novel esterified nitroalkene was capable of promoting vascular protective actions including: (a) the induction of vasorelaxation via endothelium-independent mechanisms, associated with an increase in smooth muscle cell cGMP levels, and (b) a potent dose-dependent inhibition of human platelet aggregation. We postulate that 6-AAMetNO 2 could be a potential drug for the prevention of vascular and inflammatory diseases, and the presence of the methyl group may increase its pharmacological potential.

Published
2010

5. Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

Author

Eduardo R. Migliaro, Andrés Trostchansky, Hugo Cerecetto, Gloria V. López, Mercedes González, Carlos Batthyány, Homero Rubbo, Horacio Botti, Fabiana Blanco, Rafael Radi, López Gloria V., Batthyány Carlos, Blanco Fabiana, Botti Horacio, Trostchansky Andrés, Migliaro Eduardo, Radi Rafael, González Mercedes, and Cerecetto Hugo

Subjects
Antioxidant, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, medicine.medical_treatment, Vasodilator Agents, Clinical Biochemistry, Pharmaceutical Science, Tocopherols, In Vitro Techniques, Nitric Oxide, Biochemistry, Chemical synthesis, Antioxidants, Nitric oxide, chemistry.chemical_compound, Drug Discovery, medicine, Organic chemistry, Animals, Humans, Nitric Oxide Donors, Tocopherol, Rats, Wistar, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Furoxan, Atherosclerosis, In vitro, Rats, Design synthesis, Molecular Medicine
Abstract

Postprint Synthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.

Published
2005

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