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1. Metabolite Clearance During Wakefulness and Sleep

2. GABA Receptors and the Pharmacology of Sleep

3. Adenosine and Sleep

4. Clinical Sleep–Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders

5. Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood

6. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons

7. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders

8. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept

9. Delta Opioid Receptors: Learning and Motivation

10. Delta Opioid Receptors and Cardioprotection

11. Delta Opioid Receptors and Modulation of Mood and Emotion

12. The Delta Opioid Receptor in Pain Control

13. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins

14. Ligand-Directed Signaling at the Delta Opioid Receptor

15. Delta Opioid Pharmacology in Relation to Alcohol Behaviors

16. The Roles of Opioid Receptors in Cutaneous Wound Healing

17. Gating Pore Currents in Sodium Channels

18. Sodium Channelopathies of Skeletal Muscle

19. Delta Opioid Pharmacology in Parkinson’s Disease

20. OPRD1 Genetic Variation and Human Disease

21. Cardiac Arrhythmias Related to Sodium Channel Dysfunction

22. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells

23. Toxins That Affect Voltage-Gated Sodium Channels

24. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels

25. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C

26. Voltage-Gated Sodium Channel β Subunits and Their Related Diseases

27. Structural Models of Ligand-Bound Sodium Channels

28. The Cardiac Sodium Channel and Its Protein Partners

29. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective

30. Posttranslational Modification of Sodium Channels

31. Sodium Channel Trafficking

32. Molecular and Pharmacological Mechanisms of Drug Resistance:An Evolving Paradigm

33. Resistance to Hormonal Therapy in Prostate Cancer

34. Targeting DNA Repair

35. Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer

36. Immunotolerance as a Mechanism of Resistance to Targeted Therapies in Melanoma

37. Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies

38. Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival

39. Mechanisms of Drug Resistance in Melanoma

40. Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer

41. Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia

42. Mechanisms of Resistance to Immune Checkpoint Antibodies

43. Mechanisms of Resistance in Multiple Myeloma

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