1. Impact of norepinephrine and selective β1-adrenoceptor blockers on the growth of retinal tissue explants.
- Author
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Lopatina EV, Penniyaynen VA, and Tsyrline VA
- Subjects
- Animals, Chick Embryo, Chickens, Metoprolol pharmacology, Receptors, Adrenergic metabolism, Retina embryology, Retina metabolism, Signal Transduction drug effects, Adrenergic beta-1 Receptor Antagonists pharmacology, Atenolol pharmacology, Norepinephrine pharmacology, Retina drug effects, Retina growth & development
- Abstract
We studied the effect of norepinephrine and selective β(1)-adrenoceptor blockers on the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The test drugs produced a dose-dependent effect on cell proliferation. Norepinephrine (10(-12) M) and atenolol (10(-4) M) are shown to significantly stimulate explant growth. Combined treatment with norepinephrine (10(-12) M) and atenolol (10(-4) M) results in cumulation of their stimulatory effects. The results suggest that the retina-stimulating effect of norepinephrine is based on its interactions with other types of adrenoceptors.
- Published
- 2012
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