Search

A new myrinsol diterpenoid ester, 2 α,3 β,5 α,7 β,10-O-pentacetyl-14 α-O-benzoyl-15 β-O-nicotinoyl-10,18-dihydromyrsinol ( 1), along with a known analogue, proliferin C ( 2), were isolated from the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated on the basis of spectroscopic evidence and comparison with literatures. [ABSTRACT FROM AUTHOR]

A new hygrolidin-type macrolide ( 1 ), together with one known derivative, oxohygrolidin ( 2 ), were isolated from the culture of Streptomyces sp. KIB-H869. The structure of the new compound was elucidated by means of extensive spectroscopic analysis. Moreover, by the biogenesis ratiocination and NMR data comparison, halichomycin and 2 were confirmed to have the same structure, which corrects the structural misrepresentation of halichomycin. The antifungal activities of the two compounds were evaluated. [ABSTRACT FROM AUTHOR]

Abstract: A novel polyhydroxylated C29-sterol, 25ξ-methyl-22-homo-5α-cholest-7,22-diene-3β,6β,9α-triol, designated globosterol (1), together with one known tetrahydroxylated ergosterol (22E, 24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol (2) has been isolated from the cultures of an endophytic fungus, Chaetomium globosum ZY-22 originated from the plant Ginkgo biloba. The structures and relative configurations of 1 and 2 were established on the basis of extensive spectroscopic analyses including 1D and 2D NMR (1H–1H COSY, HSQC, HMBC, and NOESY) experiments and comparison with the literature. Globosterol (1) possesses an unprecedented 25-methyl Δ22-C10-side chain and Δ7-3β,6β,9α-hydroxy-steroid nucleus, which represents the first example for C29-steroids of the group. [Copyright &y& Elsevier]