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Your search keyword '"Frick, Jeffery A."' showing total 1 results
Start Over Author "Frick, Jeffery A." Topic nucleophilic reactions
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1. Studies on the ring opening reactions of 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones. Synthesis of aminomethyl oxazolidinones and aziridinyl ureas

Author

Wells, Greggory M., Dudding, Travis, Belding, Lee, Frick, Jeffery A., Nayek, Abhijit, Huang, Junfeng, Katz, Steven J., and Bergmeier, Stephen C.

Subjects
*RING-opening reactions, *AZA compounds, *HEXANE, *ORGANIC synthesis, *OXAZOLIDINONES, *UREA, *AZIRIDINES, *NUCLEOPHILIC reactions
Abstract

Abstract: The reaction of fused ring aziridines, 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones, with amine nucleophiles can provide either an aminomethyl oxazolidinone or an aziridinyl urea. The amine, reaction solvent, and aziridine substitution have been examined with the aid of computational studies to identify reaction conditions that provide a single product. Polar solvents provided only the aminomethyl oxazolidinone products. Formation of aziridinyl ureas required control of aziridine substitution, solvent, and reactant stoichiometry. [Copyright &y& Elsevier]

Published
2012
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