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A practical and operationally simple protocol for the assembly of 6-aryl-substituted purines through the direct C6-H arylation of purines and 8-azapurine and purine nucleosides from arylboronic acids was developed. This reaction was performed under ambient conditions with ammonium persulfate as the oxidant in the presence of silver(I). The reaction was found to be regioselective with the arylation occurring predominantly at the C6 position, and a large variety of functional groups, including halides, esters, hydroxy groups, and heterocycles, were tolerated. [ABSTRACT FROM AUTHOR]

The cover picture shows a silver‐colored statue with a hand holding a triple helix, which can be found at the campus of the Beijing University of Chemical Technology. This DNA‐like statue represents step‐by‐step chemical transformations, in this case the silver‐catalyzed cross‐coupling of purines and aryl boronic acids, shown as different balls at the bottom of the helix, to afford the final C6‐arylated product, shown as the single ball at the top. Details are discussed in the Communication by N. Chen, H. Du et al. on page 3415 ff (https://doi.org/10.1002/ejoc.201700406). [ABSTRACT FROM AUTHOR]