1. JC virus in the Irish population: Significant increase of genotype 2 in immunocompromised individuals.
- Author
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Schaffer, Kirsten, Sheehy, Noreen, Coughlan, Suzie, Bergin, Colm, and Hall, William W.
- Subjects
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POLYOMAVIRUS diseases , *URINE , *HIV-positive persons , *RHEUMATOID arthritis , *NUCLEOTIDE sequence - Abstract
The human polyomavirus JC virus (JCV) is ubiquitous and can be shed in the urine of more than 40% of the healthy population. Amplification and sequencing of JCV from urine has allowed a distinctive map of the distribution of JCV genotypes worldwide. To define the frequency of JCV urinary excretion and genotype distribution in Ireland, urines from 121 healthy individuals and from 94 immunocompromised individuals (human immunodeficiency virus [HIV]-positive patients and rheumatoid arthritis patients) were collected. JCV DNA was detected by polymerase-chain reaction (PCR) with subsequent nucleotide sequencing of a fragment of the major capsid protein (VP1). JCV was detected in 20.7% of healthy individuals and was found significantly more often in the urine of HIV-positive patients (54.2%; P [ABSTRACT FROM AUTHOR]
- Published
- 2006
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