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Start Over Author "MA Yue-Hong" Topic nude mouse
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1. Transgenic Nude Mouse with Green Fluorescent Protein Expression-Based Human Glioblastoma Multiforme Animal Model with EGFR Expression and Invasiveness.

Author

Tan, Guo-Wei, Lan, Fo-Lin, Gao, Jian-Guo, Jiang, Cai-Mou, Zhang, Yi, Huang, Xiao-Hong, Ma, Yue-Hong, Shao, He-Dui, He, Xue-Yang, Chen, Jin-Long, Long, Jian-Wu, Xiao, Hui-Sheng, Guo, Zhi-Tong, and Diao, Yi

Subjects
GLIOBLASTOMA multiforme, NUDE mouse, GREEN fluorescent protein, EPIDERMAL growth factor receptors, CANCER invasiveness, TUMOR growth, ANIMAL models of tumors
Abstract

Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic xenografts labeled by phycoerythrin fluorescing red showed high EGFR expression profile, and invasive behavior under a bright green-red dual-color fluorescence background. A striking advantage in the present human GBM model is that the change of tumor growth can be observed visually instead of sacrificing animals in our further antitumor therapy studies. [ABSTRACT FROM AUTHOR]

Published
2012
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