17 results on '"Bergmann Manuela M"'
Search Results
2. Fruit and vegetable intake and cause-specific mortality in the EPIC study
- Author
-
Leenders, Max, Boshuizen, Hendriek C., Ferrari, Pietro, Siersema, Peter D., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H. M., Weiderpass, Elisabete, Engeset, Dagrun, Braaten, Tonje, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, María-José, Amiano, Pilar, Huerta, José-María, Ardanaz, Eva, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Winkvist, Anna, Khaw, Kay-Tee, Wareham, Nick J., Key, Timothy J., Bradbury, Kathryn E., Johansson, Mattias, Licaj, Idlir, Gunter, Marc J., Murphy, Neil, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
- Published
- 2014
3. Ethanol Intake and the Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
-
Rohrmann, Sabine, Linseisen, Jakob, Vrieling, Alina, Boffetta, Paolo, Stolzenberg-Solomon, Rachael Z., Lowenfels, Albert B., Jensen, Majken K., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, G., Misirli, Gesthimani, Lagiou, Pagona, Trichopoulou, Antonia, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Roddam, Andrew, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H. M., Hjartåker, Anette, Lund, Eiliv, Cornejo, Ma Luisa Redondo, Agudo, Antonio, Arriola, Larraitz, Sánchez, Maria-José, Tormo, María-José, Gurrea, Aurelio Barricarte, Lindkvist, Björn, Manjer, Jonas, Johansson, Ingegerd, Ye, Weimin, Slimani, Nadia, Duell, Eric J., Jenab, Mazda, Michaud, Dominique S., Mouw, Traci, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
- Published
- 2009
- Full Text
- View/download PDF
4. Fruit and Vegetable Consumption and Lymphoma Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
-
Rohrmann, Sabine, Becker, Nikolaus, Linseisen, Jakob, Nieters, Alexandra, Rüdiger, Thomas, Raaschou-Nielsen, Ole, Tjønneland, Anne, Johnsen, Hans E., Overvad, Kim, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Benetou, Vasiliki, Psaltopoulou, Theodora, Trichopoulou, Antonia, Masala, Giovanna, Mattiello, Amalia, Krogh, Vittorio, Tumino, Rosario, Van Gils, Carla H., Peeters, Petra H. M., Bueno-De-Mesquita, H. Bas, Ros, Martine M., Lund, Eiliv, Ardanaz, Eva, Chirlaque, María-Dolores, Jakszyn, Paula, Larrañaga, Nerea, Losada, A., Martínez-García, Carmen, Ågren, Åsa, Hallmans, Göran, Berglund, Göran, Manjer, Jonas, Allen, Naomi E., Key, Timothy J., Bingham, Sheila, Khaw, Kay Tee, Slimani, Nadia, Ferrari, Pietro, Boffetta, Paolo, Norat, Teresa, Vineis, Paolo, and Riboli, Elio
- Published
- 2007
- Full Text
- View/download PDF
5. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries
- Author
-
Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, van der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Réseau National Alimentation Cancer Recherche (réseau NACRe), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health, Imperial College London, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Institute of Nutrition Science, University of Potsdam, Hellenic Health Foundation, 'Attikon' University Hospital, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], AOU Federico II, Partenaires INRAE, Provincial Health Services Authority, Center for Cancer Prevention (CPO-Piemonte), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], The Arctic University of Norway (UiT), Public Health Directorate, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Andalusian School of Public Health [Granada], Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain, parent, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Navarra Institute for Health Research, Biodonostia Health Research Institute, Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède], Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, University of Cambridge School of Clinical Medicine, University of Ioannina School of Medicine, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], French National Cancer Institute (INCa)-Canceropole Ile-de-France 2017-1-PL SHS-01-INSERM ADR 5-1Fondation Recherche Medicale ARF201809007046European CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeFederal Ministry of Education & Research (BMBF)Hellenic Health Foundation (Greece)Associazione Italiana per la Ricerca sul Cancro (AIRC)Italian National Research CouncilDutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de Andalucia Regional government of Asturias (Spain) Regional government of Basque Country (Spain) Regional government of Murcia (Spain) Regional government of Navarra (Spain) Catalan Institute of Oncology (Spain)Swedish Cancer Society Swedish Scientific Council (Sweden) County councils of Skane and Vasterbotten (Sweden)Cancer Research UK C864/A14136 C8221/A19170Medical Research Council UK (MRC) MR/N003284/1 - MC-UU_12015/1 - MR/M012190/1 - MC_UU_12015/1 - MC_UU_12015/5 - National Institute for Health Research Biomedical Research Centre, Cambridge: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, Deschasaux, Mélanie [0000-0002-3359-420X], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,1117 Public Health and Health Services ,Cohort Studies ,Food Preferences ,Food Labeling ,General & Internal Medicine ,Surveys and Questionnaires ,Mortalitat ,Humans ,Mortality ,Nutrició ,ComputingMilieux_MISCELLANEOUS ,Nutrition ,Proportional Hazards Models ,Research ,Klinisk medicin ,1103 Clinical Sciences ,Middle Aged ,Europe ,Nutrition Assessment ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Clinical Medicine ,Nutritive Value ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, PConclusions: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.
- Published
- 2020
6. No controversial role of alcohol consumption in the development of inflammatory bowel diseases
- Author
-
Bergmann, Manuela M., Hernandez, Vicent, and Hart, Andrew
- Subjects
Crohn's disease -- Risk factors ,Digestive system research ,Ulcerative colitis -- Risk factors ,Drinking (Alcoholic beverages) -- Health aspects ,Inflammatory bowel diseases ,Medical schools ,Human nutrition ,Gastrointestinal diseases ,Nutrition ,Colitis ,Epidemiology ,Food/cooking/nutrition ,Health - Abstract
Author(s): Manuela M. Bergmann [sup.1] , Vicent Hernandez [sup.2] , Andrew Hart [sup.3] [sup.4] Author Affiliations: (1) Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Potsdam, Germany (2) Department [...]
- Published
- 2018
- Full Text
- View/download PDF
7. Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.
- Author
-
Jakszyn, Paula, Cayssials, Valerie, Buckland, Genevieve, Perez‐Cornago, Aurora, Weiderpass, Elisabete, Boeing, Heiner, Bergmann, Manuela M., Vulcan, Alexandra, Ohlsson, Bodil, Masala, Giovanna, Cross, Amanda J., Riboli, Elio, Ricceri, Fulvio, Dahm, Christina C., Nyvang, Dorthe, Katzke, Verena A., Kühn, Tilman, Kyrø, Cecilie, Tjønneland, Anne, and Ward, Heather A.
- Subjects
COLORECTAL cancer ,PHYSICAL activity ,DIET ,NUTRITION ,CANCER in men ,HEREDITARY nonpolyposis colorectal cancer - Abstract
Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite‐ and sex‐specific associations. The relationship between CRC and combined lifestyle‐related factors that contribute toward a low‐grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed‐up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04–1.27) for CRC, 1.24 (95% CI 1.09–1.41) for colon cancer and 0.99 (95% CI 0.83–1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31–2.01) for colon cancer overall and 2.11 (95% CI 1.50–2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men. What's new? Chronic inflammation has been implicated in colorectal cancer (CRC), and diet plays an important role in modulating systemic inflammation. Two additional factors that contribute to chronic inflammation and also increase CRC risk are adiposity and lack of physical activity. In this large prospective study, the authors gained further insight into these relationships. They found that pro‐inflammatory diets and a higher Inflammatory Profile Score (IPS, based on diet, physical activity, and abdominal obesity) are strong predictors of CRC, but principally of colon cancer and especially in men. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
8. Validation of Anthropometric Indices of Adiposity against Whole-Body Magnetic Resonance Imaging – A Study within the German European Prospective Investigation into Cancer and Nutrition (EPIC) Cohorts.
- Author
-
Neamat-Allah, Jasmine, Wald, Diana, Hüsing, Anika, Teucher, Birgit, Wendt, Andrea, Delorme, Stefan, Dinkel, Julien, Vigl, Matthaeus, Bergmann, Manuela M., Feller, Silke, Hierholzer, Johannes, Boeing, Heiner, and Kaaks, Rudolf
- Subjects
ANTHROPOMETRY ,OBESITY ,WHOLE body imaging ,MAGNETIC resonance imaging ,CANCER research ,PUBLIC health - Abstract
Background: In epidemiological studies, measures of body fat generally are obtained through anthropometric indices such as the body mass index (BMI), waist (WC), and hip circumferences (HC). Such indices, however, can only provide estimates of a person’s true body fat content, overall or by adipose compartment, and may have limited accuracy, especially for the visceral adipose compartment (VAT). Objective: To determine the extent to which different body adipose tissue compartments are adequately predicted by anthropometry, and to identify anthropometric measures alone, or in combination to predict overall adiposity and specific adipose tissue compartments, independently of age and body size (height). Methods: In a sub-study of 1,192 participants of the German EPIC (European Prospective Investigation into Cancer and Nutrition) cohorts, whole-body MRI was performed to determine adipose and muscle tissue compartments. Additional anthropometric measurements of BMI, WC and HC were taken. Results: After adjusting for age and height, BMI, WC and HC were better predictors of total body volume (TBV), total adipose tissue (TAT) and subcutaneous adipose tissue (SAT) than for VAT, coronary adipose tissue (CAT) and skeletal muscle tissue (SMT). In both sexes, BMI was the best predictor for TBV (men: r = 0.72 [0.68–0.76], women: r = 0.80 [0.77–0.83]) and SMT (men: r = 0.52 [0.45–0.57], women: r = 0.48 [0.41–0.54]). WC was the best predictor variable for TAT (r = 0.48 [0.41–0.54]), VAT (r = 0.44 [0.37–0.50]) and CAT (r = 0.34 [0.26–0.41]) (men), and for VAT (r = 0.42 [0.35–0.49]) and CAT (r = 0.29 [0.22–0.37]) (women). BMI was the best predictor for TAT (r = 0.49 [0.43–0.55]) (women). HC was the best predictor for SAT (men (r = 0.39 [0.32–0.45]) and women (r = 0.52 [0.46–0.58])). Conclusions: Especially the volumes of internal body fat compartments are poorly predicted by anthropometry. A possible implication may be that associations of chronic disease risks with the sizes of internal body fat as measured by BMI, WC and HC may be strongly underestimated. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
9. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC.
- Author
-
Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A., Muller, David C., Papadopoulou, Areti, Heath, Alicia K., Critselis, Elena, Gunter, Marc J., Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A., Lopez, David S., Bergmann, Manuela M., Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, and Srour, Bernard
- Abstract
Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
10. Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
- Author
-
Murphy, Neil, Norat, Teresa, Ferrari, Pietro, Jenab, Mazda, Bueno-de-Mesquita, Bas, Skeie, Guri, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Nailler, Laura, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Lagiou, Pagona, and Trichopoulos, Dimitrios
- Subjects
DAIRY products ,FOOD consumption ,COLON cancer ,CALCIUM content of food ,FAT content of food ,LONGITUDINAL method - Abstract
Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between intakes of total milk and milk subtypes (whole-fat, semi-skimmed and skimmed), yoghurt, cheese, and dietary calcium with colorectal cancer risk amongst 477,122 men and women. Dietary questionnaires were administered at baseline. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for relevant confounding variables. Results: During the mean 11 years of follow-up, 4,513 incident cases of colorectal cancer occurred. After multivariable adjustments, total milk consumption was inversely associated with colorectal cancer risk (HR per 200 g/day 0.93, 95% CI: 0.89–0.98). Similar inverse associations were observed for whole-fat (HR per 200 g/day 0.90, 95% CI: 0.82–0.99) and skimmed milk (HR per 200 g/day 0.90, 95% CI: 0.79–1.02) in the multivariable models. Inverse associations were observed for cheese and yoghurt in the categorical models; although in the linear models, these associations were non-significant. Dietary calcium was inversely associated with colorectal cancer risk (HR per 200 mg/day 0.95, 95% CI: 0.91–0.99); this association was limited to dairy sources of calcium only (HR per 200 mg/day 0.95, 95% CI: 0.91–0.99), with no association observed for non-dairy calcium sources (HR per 200 mg/day 1.00, 95% CI: 0.81–1.24). Conclusions: Our results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk. The inverse associations we observed did not differ by the fat content of the dairy products considered. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
11. Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study.
- Author
-
May, Anne M., Romaguera, Dora, Travier, Noémie, Ekelund, Ulf, Bergmann, Manuela M., Kaaks, Rudolf, Teucher, Birgit, Steffen, Annika, Boeing, Heiner, Halkjaer, Jytte, Tjonneland, Anne, Jakobsen, Marianne Uhre, Overvad, Kim, Dartois, Laureen, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Quirós, J. Ramón, Agudo, Antonio, Gonzalez, Carlos, and Sánchez, María-José
- Subjects
WAIST circumference ,BODY weight ,BODY size ,PHYSICAL fitness ,HEALTH ,SMOKING ,NUTRITION - Abstract
Background: The evidence that individual dietary and lifestyle factors influence a person's weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference. Methods: We used data of the prospective EPIC-PANACEA study. Between 1992 and 2000, 325,537 participants (94,445 men and 231,092 women, aged between 25-70) were recruited from nine European countries. Participants were categorised into two groups (positive or negative health behaviours) for each of the following being physically active, adherent to a healthy (Mediterranean not including alcohol) diet, and never-smoking for a total score ranging from zero to three. Anthropometric measures were taken at baseline and were mainly self-reported after a medium follow-up time of 5 years. Results: Mixed-effects linear regression models adjusted for age, educational level, alcohol consumption, baseline body mass index and follow-up time showed that men and women who reported to be physically active, never-smoking and adherent to the Mediterranean diet gained over a 5-year period 537 (95% CI -706, -368) and 200 (-478, -87) gram less weight and 0.95 (-1.27, -0.639) and 0.99 (-1.29, -0.69) cm less waist circumference, respectively, compared to participants with zero healthy behaviours. Conclusion: The combination of positive health behaviours was associated with significantly lower weight and waist circumference gain. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
12. Bioethical Considerations for Human Nutrigenomics.
- Author
-
Bergmann, Manuela M., Görman, Ulf, and Mathers, John C.
- Subjects
- *
BIOETHICS , *SCIENCE & ethics , *NUTRITION , *DIET , *RESEARCH ethics , *GENOMICS - Abstract
This article gives an overview of the ethical issues in nutrigenomics research and personalized nutrition. The principles of research ethics, i.e., autonomy, beneficence, nonmalfeasance, and justice, are challenged by rapidly growing cross-border research activities utilizing existing and upcoming biobanks for studies of the interaction of genes with diet on risk of common diseases. We highlight the ethical issues, some unresolved, in international collaborative projects of which researchers should be aware. Personalized nutrition (tailoring diet on the basis of genotype) is one possible application of nutrigenomics research. However, until the scientific evidence concerning diet—gene interactions is much more robust, the provision of personalized dietary advice on the basis of specific genotype remains questionable. From the ethical and social perspective, nutrigenomics offers significant opportunities to improve public health by enhancing understanding of the mechanisms through which diet can be used to reduce the risk of common polygenic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
13. Diet in the Aetiology of Ulcerative Colitis: A European Prospective Cohort Study.
- Author
-
Hart, Andrew R., Luben, Robert, Olsen, Anja, Tjonneland, Anne, Linseisen, Jakob, Nagel, Gabriele, Berglund, Göran, Lindgren, Stefan, Grip, Olof, Key, Timothy, Appleby, Paul, Bergmann, Manuela M., Boeing, Heiner, Hallmans, Göran, Danielsson, Åke, Palmqvist, Richard, Sjodin, Hubert, Hägglund, Gun, Overvad, Kim, and Palli, Domenico
- Subjects
ULCERATIVE colitis ,ETIOLOGY of diseases ,DIET in disease ,NUTRITION ,UNSATURATED fatty acids in human nutrition - Abstract
Background/Aims: The causes of ulcerative colitis are unknown, although it is plausible that dietary factors are involved. Case-control studies of diet and ulcerative colitis are subject to recall biases. The aim of this study was to examine the prospective relationship between the intake of nutrients and the development of ulcerative colitis in a cohort study. Methods: The study population was 260,686 men and women aged 20–80 years, participating in a large European prospective cohort study (EPIC). Participants were residents in the UK, Sweden, Denmark, Germany or Italy. Information on diet was supplied and the subjects were followed up for the development of ulcerative colitis. Each incident case was matched with four controls and dietary variables were divided into quartiles. Results: A total of 139 subjects with incident ulcerative colitis were identified. No dietary associations were detected, apart from a marginally significant positive association with an increasing percentage intake of energy from total polyunsaturated fatty acids (trend across quartiles OR = 1.19 (95% CI = 0.99–1.43) p = 0.07). Conclusions: No associations between ulcerative colitis and diet were detected, apart from a possible increased risk with a higher total polyunsaturated fatty acid intake. A biological mechanism exists in that polyunsaturated fatty acids are metabolised to pro-inflammatory mediators. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
14. The Relation between Dietary Protein, Calcium and Bone Health in Women: Results from the EPIC-Potsdam Cohort.
- Author
-
Weikert, Cornelia, Walter, Dietmar, Hoffmann, Kurt, Kroke, Anja, Bergmann, Manuela M., and Boeing, Heiner
- Subjects
LOW-protein diet ,CALCIUM ,WOMEN'S health ,NUTRITION ,REGRESSION analysis - Abstract
Background/Aims: The role of dietary protein in bone health is controversial. The objective of the present study was to examine the association between protein intake, dietary calcium, and bone structure measured by broadband ultrasound attenuation (BUA). Methods: Our analysis includes 8,178 female study participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) Potsdam Study. Ultrasound bone measurements were performed on the right os calcis, and BUA was determined. Dietary intake was assessed by a standardized food frequency questionnaire. We applied linear regression models to estimate the association between dietary protein and BUA. Results: After multivariate adjustment, high intake of animal protein was associated with decreased BUA values (β = –0.03; p = 0.010) whereas high vegetable protein intake was related to an increased BUA (β = 0.11; p = 0.007). The effect of dietary animal protein on BUA was modified by calcium intake. Conclusion: High consumption of protein from animal origin may be unfavourable, whereas a higher vegetable protein intake may be beneficial for bone health. Our results strengthen the hypothesis that high calcium intake combined with adequate protein intake based on a high ratio of vegetable to animal protein may be protective against osteoporosis. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
15. Food groups as predictors for short-term weight changes in men and women of the EPIC-Potsdam cohort.
- Author
-
Schulz, Mandy, Kroke, Anja, Liese, Angela D., Hoffmann, Kurt, Bergmann, Manuela M., and Boeing, Heiner
- Subjects
NUTRITION ,BODY weight ,COMPARATIVE studies ,DIET ,FAT content of food ,INGESTION ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,OBESITY ,QUESTIONNAIRES ,REGRESSION analysis ,RESEARCH ,SEX distribution ,SMOKING ,SURVEYS ,WEIGHT loss ,WEIGHT gain ,EVALUATION research ,CROSS-sectional method ,ODDS ratio - Abstract
This study examined the effect of food group intake on subsequent 2-y weight change. Food-frequency questionnaire-based food intake data of 17,369 nonsmoking subjects of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort were examined in their relation to a subsequent weight change. Dietary data, collected from 1994 to 1998, were grouped into 24 food groups. Weight change per year follow-up was the outcome of interest; large weight gain was defined as > or =2 kg; small weight gain as > or =1 kg to <2 kg; large weight loss as < or = -2 kg; small weight loss as < or = -1 kg to > -2 kg and weight maintenance as +/- 1 kg. For each food group, a separate polytomous logistic regression model with stable weight as the reference group was constructed, controlling for age, body mass index, previous weight change, and behavioral and lifestyle factors. Odds ratios (OR) and 95% confidence intervals (CI) estimated the increase in risk associated with each 100 g/d increment in food group intake. In women, consumption of high energy, high fat food groups significantly predicted large weight gain, e.g., fats (OR = 1.75; 95% CI, 1.01-3.06), sauces (OR = 2.12; 95% CI, 1.17-3.82) and meat (OR = 1.36; 95% CI, 1.04-1.79), and the consumption of cereals predicted large weight loss (OR = 1.43; 95% CI, 1.09-1.88). In men, intake of high energy, high sugar foods, i.e., sweets, was significantly predictive of large weight gain (OR = 1.48; 95% CI, 1.03-2.13). Our data show that a diet rich in high fat and high energy foods predicts short-term weight gain even if controlled for many potential confounding factors. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
16. Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Author
-
Murphy, Neil, Norat, Teresa, Ferrari, Pietro, Jenab, Mazda, Bueno-de-Mesquita, Bas, Skeie, Guri, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie Christine, Racine, Antoine, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Trichopoulos, Dimitrios, Lagiou, Pagona, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Siersema, Peter, van Duijnhoven, Franzel, Peeters, Petra H. M., Hjartaker, Anette, Engeset, Dagrun, González, Carlos A., Sánchez, Maria-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Quirós, José R., Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena, Palmqvist, Richard, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Crowe, Francesca L., Fedirko, Veronika, Wark, Petra A., Chuang, Shu-Chun, and Riboli, Elio
- Subjects
Medicine ,Epidemiology ,Cancer Epidemiology ,Gastroenterology and Hepatology ,Colon ,Gastrointestinal Cancers ,Nutrition ,Public Health ,Preventive Medicine - Abstract
Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. Methodology/Principal Findings After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79–0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. Conclusions/Significance: Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
- Published
- 2012
- Full Text
- View/download PDF
17. Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Author
-
Fedirko, Veronika, Jenab, Mazda, Rinaldi, Sabina, Biessy, Carine, Allen, Naomi E., Dossus, Laure, Onland-Moret, N. Charlotte, Schütze, Madlen, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Kaaks, Rudolf, Lukanova, Annekatrin, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Oustoglou, Erifili, and Barbitsioti, Antonia
- Subjects
- *
ALCOHOL drinking & health , *ENDOMETRIAL cancer , *LONGITUDINAL method , *NUTRITION , *SEX hormones , *EPIDEMIOLOGY , *CONFIDENCE intervals , *LIFESTYLE Assessment Questionnaire - Abstract
Abstract: Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. Methods: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. Results: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1–6 g/d) were 1.03 (0.88–1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86–1.17) for 6.1–12 g/d, 1.03 (0.87–1.22) for 12.1–24 g/d, 1.07 (0.87–1.38) for 24.1–36 g/d, and 0.85 (0.61–1.18) for more than 36 g/d (p trend = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98–1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. Conclusions: Our findings suggest no association between alcohol intake and endometrial cancer risk. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.