1. Fuzhuan brick tea extract prevents diet-induced obesity via stimulation of fat browning in mice.
- Author
-
Yoo A, Jung Kim M, Ahn J, Hwa Jung C, Deok Seo H, Yung Ly S, and Youl Ha T
- Subjects
- Adipose Tissue, Brown metabolism, Adipose Tissue, White metabolism, Animals, Diet, High-Fat adverse effects, Energy Metabolism, Mice, Mice, Inbred C57BL, Plant Extracts metabolism, Obesity etiology, Obesity genetics, Tea metabolism
- Abstract
Fuzhuan brick tea is a post-fermented tea that is intentionally fermented by the fungus Eurotium cristatum. Previous studies have reported the anti-obesity effect of Fuzhuan brick tea extracts (FBT), but the underlying mechanism remains unclear. The present study investigated whether FBT exerts anti-obesity effects through energy expenditure and browning of white adipose tissue. Mice were administered 100 mg or 200 mg FBT/kg body weight along with a high-fat diet (HFD) for 12 weeks; the FBT group had a significantly reduced body weight and adipose tissue mass compared to mice fed an HFD alone. FBT also improved serum biochemical parameters and hepatic steatosis concomitant with obesity. Furthermore, FBT enhanced energy expenditure and promoted browning of subcutaneous adipose tissue by upregulating the expression of brown adipocyte-specific genes, including uncoupling protein 1. Based on these results, we suggest that FBT induces energy expenditure by promoting the browning of subcutaneous adipose tissue, which prevents weight gain., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF