19 results on '"Hofmeyr GJ"'
Search Results
2. Amnioinfusion for meconium-stained liquor in labour.
- Author
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Hofmeyr GJ, Xu H, and Eke AC
- Subjects
- Cesarean Section statistics & numerical data, Female, Humans, Infant, Newborn, Injections, Perinatal Mortality, Pregnancy, Randomized Controlled Trials as Topic, Amnion, Meconium, Meconium Aspiration Syndrome prevention & control, Obstetric Labor Complications prevention & control, Sodium Chloride administration & dosage
- Abstract
Background: Amnioinfusion is thought to dilute meconium present in the amniotic fluid and so reduce the risk of meconium aspiration., Objectives: To assess the effects of amnioinfusion for meconium-stained liquor on perinatal outcome., Search Methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (1 December 2013)., Selection Criteria: Randomised trials comparing amnioinfusion with no amnioinfusion for women in labour with moderate or thick meconium staining of the amniotic fluid., Data Collection and Analysis: Three review authors independently assessed eligibility and trial quality, and extracted data., Main Results: Fourteen studies of variable quality (4435 women) are included.Subgroup analysis was performed for studies from settings with limited facilities to monitor the baby's condition during labour and intervene effectively, and settings with standard peripartum surveillance.Settings with standard peripartum surveillance: there was considerable heterogeneity for several outcomes. There was no significant reduction in the primary outcomes meconium aspiration syndrome, perinatal death or severe morbidity, and maternal death or severe morbidity. There was a reduction in caesarean sections (CSs) for fetal distress but not overall. Meconium below the vocal cords diagnosed by laryngoscopy was reduced, as was neonatal ventilation or neonatal intensive care unit admission, but there was no significant reduction in perinatal deaths or other morbidity. Planned sensitivity analysis excluding trials with greater risk of bias resulted in an absence of benefits for any of the outcomes studied.Settings with limited peripartum surveillance: three studies were included. In the amnioinfusion group there was a reduction in CS for fetal distress and overall; meconium aspiration syndrome (three studies, 1144 women; risk ratio (RR) 0.17, 95% confidence interval (CI) 0.05 to 0.52); perinatal mortality (three studies, 1151 women; RR 0.24, 95% CI 0.11 to 0.53) and neonatal ventilation or neonatal intensive care unit admission. In one of the studies, meconium below the vocal cords was reduced and, in the other, neonatal encephalopathy was reduced., Authors' Conclusions: Amnioinfusion is associated with substantive improvements in perinatal outcome only in settings where facilities for perinatal surveillance are limited. It is not clear whether the benefits are due to dilution of meconium or relief of oligohydramnios.In settings with standard peripartum surveillance, some non-substantive outcomes were improved in the initial analysis, but sensitivity analysis excluding trials with greater risk of bias eliminated these differences. Amnioinfusion is either ineffective in this setting, or its effects are masked by other strategies to optimise neonatal outcome.The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2014
- Full Text
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3. Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour.
- Author
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Novikova N, Hofmeyr GJ, and Essilfie-Appiah G
- Subjects
- Female, Fetal Distress therapy, Humans, Injections, Obstetric Labor Complications prevention & control, Oligohydramnios prevention & control, Pregnancy, Randomized Controlled Trials as Topic, Amnion, Fetal Heart physiopathology, Heart Rate, Fetal physiology, Obstetric Labor Complications therapy, Oligohydramnios therapy
- Abstract
Background: Amnioinfusion aims to relieve umbilical cord compression during labour by infusing a liquid into the uterine cavity., Objectives: The objective of this review was to assess the effects of prophylactic amnioinfusion for women in labour with oligohydramnios, but not fetal heart deceleration, compared with therapeutic amnioinfusion only if fetal heart rate decelerations or thick meconium-staining of the liquor occur., Search Methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (28 February 2012)., Selection Criteria: Randomised trials comparing prophylactic amnioinfusion in women in labour with oligohydramnios but not fetal heart rate deceleration in labour with therapeutic amnioinfusion., Data Collection and Analysis: The authors assessed trial quality and extracted data., Main Results: One randomized trial of 116 women was included. No differences were found in the rate of caesarean section (risk ratio 1.29, 95% confidence interval 0.60 to 2.74). There were no differences in cord arterial pH, oxytocin augmentation, neonatal pneumonia or postpartum endometritis. Prophylactic amnioinfusion was associated with increased intrapartum fever (risk ratio 3.48, 95% confidence interval 1.21 to 10.05)., Authors' Conclusions: There appears to be no advantage of prophylactic amnioinfusion over therapeutic amnioinfusion carried out only when fetal heart rate decelerations or thick meconium-staining of the liquor occur.
- Published
- 2012
- Full Text
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4. Amnioinfusion for meconium-stained liquor in labour.
- Author
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Hofmeyr GJ and Xu H
- Subjects
- Female, Humans, Infant, Newborn, Pregnancy, Randomized Controlled Trials as Topic, Amnion, Injections, Meconium, Meconium Aspiration Syndrome prevention & control, Obstetric Labor Complications prevention & control
- Abstract
Background: Amnioinfusion is thought to dilute meconium present in the amniotic fluid and so reduce the risk of meconium aspiration., Objectives: To assess the effects of amnioinfusion for meconium-stained liquor on perinatal outcome., Search Strategy: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (May 2009)., Selection Criteria: Randomised trials comparing amnioinfusion with no amnioinfusion for women in labour with moderate or thick meconium-staining of the amniotic fluid., Data Collection and Analysis: Two review authors assessed eligibility and trial quality, and extracted data, independently., Main Results: Thirteen studies of variable quality (4143 women) are included.Subgroup analysis was performed for studies from settings with limited facilities to monitor the baby's condition during labour and intervene effectively, and settings with standard peripartum surveillance.Settings with standard peripartum surveillance: there was considerable heterogeneity for several outcomes. There was no significant reduction in the primary outcomes meconium aspiration syndrome, perinatal death or severe morbidity, and maternal death or severe morbidity. There was a reduction in caesarean sections (CSs) for fetal distress but not overall. Meconium below the vocal cords diagnosed by laryngoscopy was reduced, as was neonatal ventilation or neonatal intensive care unit admission, but there was no significant reduction in perinatal deaths or other morbidity. Planned sensitivity analysis excluding trials with greater risk of bias resulted in an absence of benefits for any of the outcomes studied.Settings with limited peripartum surveillance: two studies (855 women) were included. In the amnioinfusion group there was a reduction in CS for fetal distress and overall; meconium aspiration syndrome (RR 0.25, 95% CI 0.13 to 0.47), and neonatal ventilation or neonatal intensive care unit admission; and a trend towards reduced perinatal mortality (RR 0.37, 95% CI 0.13 to 1.01). In one of the studies, meconium below the vocal cords was reduced and, in the other, neonatal encephalopathy was reduced., Authors' Conclusions: Amnioinfusion is associated with substantive improvements in perinatal outcome only in settings where facilities for perinatal surveillance are limited. It is not clear whether the benefits are due to dilution of meconium or relief of oligohydramnios.In settings with standard peripartum surveillance, some non-substantive outcomes were improved in the initial analysis, but sensitivity analysis excluding trials with greater risk of bias eliminated these differences. Amnioinfusion is either ineffective in this setting, or its effects are masked by other strategies to optimise neonatal outcome.The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2010
- Full Text
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5. Obstetric care in low-resource settings: what, who, and how to overcome challenges to scale up?
- Author
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Hofmeyr GJ, Haws RA, Bergström S, Lee AC, Okong P, Darmstadt GL, Mullany LC, Oo EK, and Lawn JE
- Subjects
- Female, Fetal Death epidemiology, Humans, Obstetric Labor Complications epidemiology, Pregnancy, Socioeconomic Factors, Delivery, Obstetric, Developing Countries, Fetal Death prevention & control, Obstetric Labor Complications prevention & control, Prenatal Care organization & administration
- Abstract
Background: Each year, approximately 2 million babies die because of complications of childbirth, primarily in settings where effective care at birth, particularly prompt cesarean delivery, is unavailable., Objective: We reviewed the content, impact, risk-benefit, and feasibility of interventions for obstetric complications with high population attributable risk of intrapartum-related hypoxic injury, as well as human resource, skill development, and technological innovations to improve obstetric care quality and availability., Results: Despite ecological associations of obstetric care with improved perinatal outcomes, there is limited evidence that intrapartum interventions reduce intrapartum-related neonatal mortality or morbidity. No interventions had high-quality evidence of impact on intrapartum-related outcomes in low-resource settings. While data from high-resource settings support planned cesarean for breech presentation and post-term induction, these interventions may be unavailable or less safe in low-resource settings and require risk-benefit assessment. Promising interventions include use of the partograph, symphysiotomy, amnioinfusion, therapeutic maneuvers for shoulder dystocia, improved management of intra-amniotic infections, and continuous labor support. Obstetric drills, checklists, and innovative low-cost devices could improve care quality. Task-shifting to alternative cadres may increase coverage of care., Conclusions: While intrapartum care aims to avert intrapartum-related hypoxic injury, rigorous evidence is lacking, especially in the settings where most deaths occur. Effective care at birth could save hundreds of thousands of lives a year, with investment in health infrastructure, personnel, and research--both for innovation and to improve implementation.
- Published
- 2009
- Full Text
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6. WITHDRAWN: Amnioinfusion for meconium-stained liquor in labour.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Infant, Newborn, Pregnancy, Randomized Controlled Trials as Topic, Amnion, Injections, Meconium, Meconium Aspiration Syndrome prevention & control, Obstetric Labor Complications prevention & control
- Abstract
Background: Amnioinfusion aims to prevent or relieve umbilical cord compression during labour by infusing a solution into the uterine cavity. It is also thought to dilute meconium when present in the amniotic fluid and so reduce the risk of meconium aspiration. However, it may be that the mechanism of effect is that it corrects oligohydramnios (reduced amniotic fluid), for which thick meconium staining is a marker., Objectives: The objective of this review was to assess the effects of amnioinfusion for meconium-stained liquor on perinatal outcome., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register (October 2001) and the Cochrane Controlled Trials Register (Issue 3, 2001) were searched., Selection Criteria: Randomised trials comparing amnioinfusion with no amnioinfusion for women in labour with moderate or thick meconium-staining of the amniotic fluid., Data Collection and Analysis: Eligibility and trial quality were assessed by one reviewer., Main Results: Twelve studies, most involving small numbers of participants, were included. Under standard perinatal surveillance, amnioinfusion was associated with a reduction in the following: heavy meconium staining of the liquor (relative risk 0.03, 95% confidence interval 0.01 to 0.15); variable fetal heart rate deceleration (relative risk 0.65, 95% confidence interval 0.49 to 0.88); and reduced caesarean section overall (relative risk 0.82, 95% confidence interval 0.69 to 1.97). No perinatal deaths were reported. Under limited perinatal surveillance, amnioinfusion was associated with a reduction in the following: meconium aspiration syndrome (relative risk 0.24, 95% confidence interval 0.12 to 0.48); neonatal hypoxic ischaemic encephalopathy (relative risk 0.07, 95% confidence interval 0.01 to 0.56) and neonatal ventilation or intensive care unit admission (relative risk 0.56, 95% confidence interval 0.39 to 0.79); there was a trend towards reduced perinatal mortality (relative risk 0.34, 95% confidence interval 0.11 to 1.06)., Authors' Conclusions: Amnioinfusion is associated with improvements in perinatal outcome, particularly in settings where facilities for perinatal surveillance are limited. The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2009
- Full Text
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7. Evidence-based intrapartum care.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Labor Stage, Second, Labor Stage, Third, Pregnancy, Pregnancy Outcome, Randomized Controlled Trials as Topic, Trial of Labor, Delivery, Obstetric, Obstetric Labor Complications therapy
- Abstract
Routine care in normal labour may range from supportive care at home to intensive monitoring and multiple interventions in hospital. Good evidence of effectiveness is necessary to justify interventions in the normal process of labour. Inadequate evidence is available to support perineal shaving, routine enemas, starvation in labour and excluding the choice for home births. Evidence supports continuity of care led by midwives, companionship in labour, restricting the use of episiotomy, and active management of the third stage of labour, including routine use of 10 units of oxytocin. Both benefits and risks are associated with routine amniotomy, continuous electronic fetal heart rate monitoring, epidural analgesia, and oxytocin-ergometrine to prevent postpartum haemorrhage. More evidence is needed regarding the emotional consequences of labour interventions, home births, vaginal cleansing, opioid use, the partograph, second-stage labour techniques, misoprostol for primary prevention of postpartum haemorrhage, and strategies to promote evidence-based care in labour.
- Published
- 2005
- Full Text
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8. Maternal oxygen administration for fetal distress.
- Author
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Fawole B and Hofmeyr GJ
- Subjects
- Female, Humans, Pregnancy, Fetal Distress therapy, Obstetric Labor Complications therapy, Oxygen Inhalation Therapy
- Abstract
Background: Maternal oxygen administration has been used in an attempt to lessen fetal distress by increasing the available oxygen from the mother. This has been used for suspected fetal distress during labour, and prophylactically during the second stage of labour on the assumption that the second stage is a time of high risk for fetal distress., Objectives: The objective of this review was to assess the effects of maternal oxygenation for fetal distress during labour and to assess the effects of prophylactic oxygen therapy during the second stage of labour on perinatal outcome., Search Strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register (March 2003) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2002)., Selection Criteria: Randomised trials comparing maternal oxygen administration for fetal distress during labour and prophylactic oxygen administration during the second stage of labour with a control group (dummy or no oxygen therapy)., Data Collection and Analysis: Both reviewers assessed eligibility and trial quality. Data were extracted, checked and entered into RevMan software. For dichotomous data, relative risks (RR) and 95% confidence intervals (CI) were calculated. For continuous data, weighted mean differences and 95% CI were calculated., Main Results: No trials addressing maternal oxygen therapy for fetal distress were located. Two trials which addressed prophylactic oxygen administration during labour were included. Abnormal cord blood pH values (less than 7.2) were recorded significantly more frequently in the oxygenation group than the control group (relative risk 3.51, 95% confidence interval 1.34 to 9.19). There were no other statistically significant differences between the groups. There were conflicting conclusions on the effect of the duration of oxygen administration on umbilical artery pH values between the two trials., Reviewer's Conclusions: Implications for practiceThere is not enough evidence to support the use of prophylactic oxygen therapy for women in labour, nor to evaluate its effectiveness for fetal distress. Implications for researchIn view of the widespread use of oxygen administration during labour and the possibility that it may be ineffective or harmful, there is an urgent need for randomised trials to assess its effects.
- Published
- 2003
- Full Text
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9. Amnioinfusion for meconium-stained liquor in labour.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Infant, Newborn, Pregnancy, Randomized Controlled Trials as Topic, Amnion, Injections, Meconium, Meconium Aspiration Syndrome prevention & control, Obstetric Labor Complications prevention & control
- Abstract
Background: Amnioinfusion aims to prevent or relieve umbilical cord compression during labour by infusing a solution into the uterine cavity. It is also thought to dilute meconium when present in the amniotic fluid and so reduce the risk of meconium aspiration. However, it may be that the mechanism of effect is that it corrects oligohydramnios (reduced amniotic fluid), for which thick meconium staining is a marker., Objectives: The objective of this review was to assess the effects of amnioinfusion for meconium-stained liquor on perinatal outcome., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register (October 2001) and the Cochrane Controlled Trials Register (Issue 3, 2001) were searched., Selection Criteria: Randomised trials comparing amnioinfusion with no amnioinfusion for women in labour with moderate or thick meconium-staining of the amniotic fluid., Data Collection and Analysis: Eligibility and trial quality were assessed by one reviewer., Main Results: Twelve studies, most involving small numbers of participants, were included. Under standard perinatal surveillance, amnioinfusion was associated with a reduction in the following: heavy meconium staining of the liquor (relative risk 0.03, 95% confidence interval 0.01 to 0.15); variable fetal heart rate deceleration (relative risk 0.65, 95% confidence interval 0.49 to 0.88); and reduced caesarean section overall (relative risk 0.82, 95% confidence interval 0.69 to 1.97). No perinatal deaths were reported. Under limited perinatal surveillance, amnioinfusion was associated with a reduction in the following: meconium aspiration syndrome (relative risk 0.24, 95% confidence interval 0.12 to 0.48); neonatal hypoxic ischaemic encephalopathy (relative risk 0.07, 95% confidence interval 0.01 to 0.56) and neonatal ventilation or intensive care unit admission (relative risk 0.56, 95% confidence interval 0.39 to 0.79); there was a trend towards reduced perinatal mortality (relative risk 0.34, 95% confidence interval 0.11 to 1.06)., Reviewer's Conclusions: Amnioinfusion is associated with improvements in perinatal outcome, particularly in settings where facilities for perinatal surveillance are limited. The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2002
- Full Text
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10. Maternal oxygen administration for fetal distress.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Pregnancy, Fetal Distress therapy, Obstetric Labor Complications therapy, Oxygen Inhalation Therapy
- Abstract
Background: Maternal oxygen administration has been used in an attempt to lessen fetal distress by increasing the available oxygen from the mother., Objectives: The objective of this review was to assess the effects of maternal oxygenation for fetal distress during labour and to assess the effects of prophylactic oxygen therapy during the second stage of labour on perinatal outcome., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched. Date of last search: December 1997., Selection Criteria: Randomised trials comparing maternal oxygen therapy for fetal distress during labour and prophylactic oxygen therapy during the second stage of labour with a control group (dummy or no oxygen therapy)., Data Collection and Analysis: Eligibility and trial quality were assessed by the reviewer., Main Results: No trials addressing maternal oxygen therapy for fetal distress could be located. One trial of 85 women which addressed prophylactic oxygen therapy during labour was included. Cord blood pH values of less than 7.2 were more frequently recorded in the oxygenation group than the control group (relative risk 4.83, 95% confidence interval 1.11 to 21.04). There were no other statistically significant differences between the groups. Within the oxygenation group, those receiving oxygenation for less than 10 minutes had higher umbilical artery pH values than those receiving oxygen for longer than 10 minutes., Reviewer's Conclusions: There is not enough evidence to support the use of prophylactic oxygen therapy for women in labour, nor to evaluate its effectiveness for fetal distress.
- Published
- 2000
- Full Text
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11. Amnioinfusion for meconium-stained liquor in labour.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Infant, Newborn, Pregnancy, Amnion, Injections, Meconium, Meconium Aspiration Syndrome prevention & control, Obstetric Labor Complications prevention & control
- Abstract
Background: Amnioinfusion aims to prevent or relieve umbilical cord compression during labour by infusing a solution into the uterine cavity. It is also thought to dilute meconium when present in the amniotic fluid and so reduce the risk of meconium aspiration. However it may be that the mechanism of effect is that it corrects oligohydramnios (reduced amniotic fluid), for which thick meconium staining is a marker., Objectives: The objective of this review was to assess the effects of amnioinfusion for meconium-stained liquor on perinatal outcome., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched., Selection Criteria: Randomised trials comparing amnioinfusion with no amnioinfusion for women in labour with moderate or thick meconium-staining of the amniotic fluid., Data Collection and Analysis: Eligibility and trial quality were assessed by one reviewer., Main Results: Ten studies, most involving small numbers of participants, were included. Under standard perinatal surveillance, amnioinfusion was associated with a reduction in the following: heavy meconium staining of the liquor (relative risk 0.03, 95% confidence interval 0.01 to 0.15); variable fetal heart rate deceleration (relative risk 0.47, 95% confidence interval 0.24 to 0. 90); and a trend to reduced caesarean section overall (relative risk 0.83, 95% confidence interval 0.69 to 1.00). No perinatal deaths were reported. Under limited perinatal surveillance, amnioinfusion was associated with a reduction in the following: meconium aspiration syndrome (relative risk 0.24, 95% confidence interval 0. 12 to 0.48); neonatal hypoxic ischaemic encephalopathy (relative risk 0.07, 95% confidence interval 0.01 to 0.56) and neonatal ventilation or intensive care unit admission (relative risk 0.56, 95% confidence interval 0.39 to 0.79); there was a trend towards reduced perinatal mortality (relative risk 0.34, 95% confidence interval 0.11 to 1.06)., Reviewer's Conclusions: Amnioinfusion is associated with improvements in perinatal outcome, particularly in settings where facilities for perinatal surveillance are limited. The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2000
- Full Text
- View/download PDF
12. Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Pregnancy, Amnion, Injections, Obstetric Labor Complications prevention & control, Obstetric Labor Complications therapy, Oligohydramnios prevention & control, Oligohydramnios therapy
- Abstract
Background: Amnioinfusion aims to relieve umbilical cord compression during labour by infusing a liquid into the uterine cavity., Objectives: The objective of this review was to assess the effects of prophylactic amnioinfusion for oligohydramnios compared with therapeutic amnioinfusion only if fetal heart rate decelerations or thick meconium-staining of the liquor occur., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register and Cochrane Controlled Trials Register were searched. Date of last search: October 1997., Selection Criteria: Randomised trials comparing prophylactic with therapeutic amnioinfusion in women with oligohydramnios but not fetal heart rate deceleration in labour., Data Collection and Analysis: The reviewer assessed trial quality and extracted data., Main Results: Two studies of 285 women were included. No differences were found in the rate of caesarean section (relative risk 0.98, 95% confidence interval 0.58 to 1.66), or forceps delivery. There were no difference in Apgar scores, cord arterial pH, oxytocin augmentation, meconium aspiration, neonatal pneumonia or postpartum endometritis. Prophylactic amnioinfusion was associated with increased intrapartum fever (relative risk 3.48, 95% confidence interval 1.21 to 10.05)., Reviewer's Conclusions: There appears to be no advantage of prophylactic amnioinfusion over therapeutic amnioinfusion carried out only when fetal heart rate decelerations or thick meconium-staining of the liquor occur.
- Published
- 2000
- Full Text
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13. Tocolytics for suspected intrapartum fetal distress.
- Author
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Kulier R and Hofmeyr GJ
- Subjects
- Female, Hexoprenaline therapeutic use, Humans, Magnesium Sulfate therapeutic use, Pregnancy, Terbutaline therapeutic use, Fetal Distress drug therapy, Obstetric Labor Complications drug therapy, Tocolytic Agents therapeutic use
- Abstract
Background: Prophylactic tocolysis with betamimetics and other agents has become widespread as a treatment for fetal distress. Uterine relaxation may improve placental blood flow and therefore fetal oxygenation. However there may also be adverse maternal cardiovascular effects., Objectives: The objective of this review was to assess the effects of tocolytic therapy for suspected fetal distress on fetal, maternal and perinatal outcomes., Search Strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register. Date of last search: February 1999., Selection Criteria: Randomised trials comparing tocolytic therapy with no treatment or treatment with another tocolytic agent for suspected fetal distress., Data Collection and Analysis: Two reviewers assessed trial quality and extracted data., Main Results: Three studies were included. Compared with no treatment, there were fewer failed improvements in fetal heart rate abnormalities with tocolytic therapy (relative risk 0.26, 95% 0.13 to 0.53). Betamimetic therapy compared with magnesium sulphate showed a non-significant trend towards reduced uterine activity (relative risk 0.07, 95% confidence interval 0.00 to 1.10)., Reviewer's Conclusions: Betamimetic therapy appears to be able to reduce the number of fetal heart rate abnormalities and perhaps reduce uterine activity. However there is not enough evidence based on clinically important outcomes to evaluate the use of betamimetics for suspected fetal distress.
- Published
- 2000
- Full Text
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14. Amnioinfusion for umbilical cord compression in labour.
- Author
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Hofmeyr GJ
- Subjects
- Female, Humans, Pregnancy, Umbilical Cord, Amnion, Chorioamnionitis prevention & control, Injections, Obstetric Labor Complications prevention & control
- Abstract
Background: Amnioinfusion aims to prevent or relieve umbilical cord compression during labour by infusing a solution into the uterine cavity., Objectives: The objective of this review was to assess the effects of amnioinfusion on maternal and perinatal outcome for potential or suspected umbilical cord compression or potential amnionitis., Search Strategy: The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched., Selection Criteria: Randomised trials of amnioinfusion compared with no amnioinfusion in women with babies at risk of umbilical cord compression; and women at risk of intrauterine infection., Data Collection and Analysis: Eligibility and trial quality were assessed by the reviewer., Main Results: Twelve studies were included. Transcervical amnioinfusion for potential or suspected umbilical cord compression was associated with the following reductions: fetal heart rate decelerations (relative risk 0.54, 95% confidence interval 0.43 to 0.68); caesarean section for suspected fetal distress (relative risk 0.35, 95% confidence interval 0.24 to 0.52); neonatal hospital stay greater than 3 days (relative risk 0.40, 95% confidence interval 0. 26 to 0.62); maternal hospital stay greater than 3 days (relative risk 0.46, 95% 0.29 to 0.74). Transabdominal amnioinfusion showed similar results. Transcervical amnioinfusion to prevent infection in women with membranes ruptured for more than 6 hours was associated with a reduction in puerperal infection (relative risk 0.50, 95% confidence interval 0.26 to 0.97)., Reviewer's Conclusions: Amnioinfusion appears to reduce the occurrence of variable heart rate decelerations and lower the use of caesarean section. However the studies were done in settings where fetal distress was not confirmed by fetal blood sampling. The results may therefore only be relevant where caesarean sections are commonly done for abnormal fetal heart rate alone. The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
- Published
- 2000
- Full Text
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15. The Collaborative Randomised Amnioinfusion for Meconium Project (CRAMP): 2. Zimbabwe.
- Author
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Mahomed K, Mulambo T, Woelk G, Hofmeyr GJ, and Gülmezoğlu AM
- Subjects
- Abnormalities, Multiple etiology, Adult, Cesarean Section, Female, Fetal Death etiology, Hospitalization, Humans, Infant, Newborn, Intensive Care, Neonatal, Meconium Aspiration Syndrome etiology, Pregnancy, Pregnancy Outcome, Urban Health, Zimbabwe, Amnion, Meconium, Obstetric Labor Complications prevention & control, Sodium Chloride administration & dosage
- Abstract
Objective: To evaluate transcervical amnioinfusion for meconium stained amniotic fluid during labour., Design: Multicentre randomised controlled trial., Setting: A large urban academic hospital. Electronic fetal heart rate monitoring was not used., Participants: Women in labour at term with moderate or thick meconium staining of the amniotic fluid., Interventions: Transcervical amnioinfusion of 500 mL saline over 30 minutes, then 500 mL at 30 drops per minute. The control group received routine care. Blinding of the intervention was not possible., Main Outcome Measures: Caesarean section, meconium aspiration syndrome and perinatal mortality., Results: There was no difference in risk for caesarean section in the two groups (amnioinfusion 9.5% vs control 12.3%; RR 0.84, 95% CI 0.53-1.32). Meconium aspiration syndrome was significantly less frequent in the amnioinfusion group (3.1% vs 12.8%; RR 0.24, 95% CI 0.12-0.48), and there was a trend towards fewer perinatal deaths (1.2% vs 3.6%; RR 0.34, 95% CI 0.11-1.06)., Conclusions: Amnioinfusion is technically feasible in a developing country situation with limited intrapartum facilities. In this study amnioinfusion for meconium stained amniotic fluid was associated with striking improvements in perinatal outcome.
- Published
- 1998
- Full Text
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16. The Collaborative Randomised Amnioinfusion for Meconium Project (CRAMP): 1. South Africa.
- Author
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Hofmeyr GJ, Gülmezoğlu AM, Buchmann E, Howarth GR, Shaw A, Nikodem VC, Cronje H, de Jager M, and Mahomed K
- Subjects
- Cesarean Section, Female, Humans, Infant, Newborn, Meconium Aspiration Syndrome prevention & control, Pregnancy, South Africa, Urban Health, Amnion, Meconium, Obstetric Labor Complications prevention & control, Sodium Chloride administration & dosage
- Abstract
Objective: To evaluate transcervical amnioinfusion for meconium stained amniotic fluid during labout., Design: Multicentre randomised controlled trial., Setting: Four urban academic hospitals in South Africa. Obstetric surveillance included the use of electronic fetal heart rate monitoring in most cases., Participants: Women in labour at term with moderate or thick meconium staining of the amniotic fluid., Interventions: Transcervical amnioinfusion of 800 mL saline at 15 mL per minute, followed by a maintenance infusion at 3 mL per minute. The control group received routine care. Blinding of the intervention was not possible., Main Outcome Measures: Caesarean section, meconium aspiration syndrome and perinatal mortality., Results: Caesarean section rates were similar (amnioinfusion group 70/167 vs control group 68/159; RR 0.98, 95% CI 0.76-1.26). The incidence of meconium aspiration syndrome was lower than expected on the basis of previous studies (4/162 vs 6/163; RR 0.67, 95% CI 0.19-2.33). There were no perinatal deaths. There were no significant differences between any of the subsidiary outcomes., Conclusions: This study concurred with three previous trials which found no effect of amnioinfusion for meconium-stained amniotic fluid on caesarean section rate, though the pooled data from all identified trials to date show a significant reduction. The findings with respect to meconium aspiration syndrome were inconclusive in this study alone because of the small number of babies affected, but the point estimate of the relative risk was consistent with the finding of a significant reduction in previous studies and with the Zimbabwe arm (CRAMP 2) of this study. Pooled data clearly support the use of amnioinfusion for meconium stained amniotic fluid to reduce the incidence of meconium aspiration syndrome.
- Published
- 1998
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17. Amnioinfusion: a question of benefits and risks.
- Author
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Hofmeyr GJ
- Subjects
- Catheterization, Peripheral, Drug Administration Routes, Female, Heart Rate, Fetal, Humans, Pregnancy, Uterine Contraction, Amnion, Obstetric Labor Complications etiology
- Published
- 1996
- Full Text
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18. Effect of external cephalic version in late pregnancy on breech presentation and caesarean section rate: a controlled trial.
- Author
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Hofmeyr GJ
- Subjects
- Adult, Clinical Trials as Topic, Female, Fetal Heart physiology, Fetal Monitoring, Humans, Pregnancy, Pregnancy Trimester, Third, Random Allocation, Ultrasonography, Breech Presentation, Cesarean Section, Delivery, Obstetric, Labor Presentation, Obstetric Labor Complications prevention & control, Version, Fetal
- Abstract
A prospective randomized controlled trial of external cephalic version (ECV) in late pregnancy is reported. All pregnancies were assessed with ultrasound and cardiotocography. ECV was successful in 29 out of 30 patients (97%). Breech presentation at delivery occurred in 67% of the control group and in 3% of the ECV group. The caesarean section rates were 43 and 20% respectively. Tocolysis was used in seven patients. A new technique of ECV with the steep lateral position is described. Complications were limited to cardiotocographic changes and one patient with unexplained vaginal spotting. The procedure is recommended provided appropriate patient selection and surveillance is practised.
- Published
- 1983
- Full Text
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19. Labour after caesarean section--the problem of scar dehiscence.
- Author
-
Davey MR, Moodley J, and Hofmeyr GJ
- Subjects
- Adult, Cicatrix, Female, Humans, Pregnancy, Prospective Studies, Reoperation, Cesarean Section adverse effects, Obstetric Labor Complications etiology, Surgical Wound Dehiscence
- Abstract
Conventional criteria for the prediction and diagnosis of dehiscence of a caesarean section scar during labour were prospectively evaluated. Of 70 patients selected to undergo trial of labour, scar dehiscence occurred in 2 of 35 mothers delivered vaginally and in 4 delivered by caesarean section. Conventional predictive and diagnostic criteria correlated poorly with the occurrence of scar dehiscence. These limitations should be recognised and, during trial of labour after caesarean section, emphasis should be placed on careful monitoring of maternal and fetal condition.
- Published
- 1987
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