1. Possible mechanism of pesticide toxicity-related oxidative stress leading to airway narrowing.
- Author
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Kesavachandran C, Singh VK, Mathur N, Rastogi SK, Siddiqui MK, Reddy MM, Bharti RS, and Khan AM
- Subjects
- Adolescent, Adult, Airway Obstruction blood, Airway Obstruction etiology, Antioxidants metabolism, Cholinesterases blood, Cross-Sectional Studies, Glutathione blood, Humans, Male, Malondialdehyde blood, Pesticide Residues blood, Airway Obstruction physiopathology, Occupational Exposure adverse effects, Oxidative Stress, Pesticides poisoning
- Abstract
The study was conducted to assess the magnitude of oxidative stress and lung function abnormalities in 34 male pesticide sprayers on exposure to pesticides in mango plantations. Biochemical studies on blood antioxidant enzymes revealed an unchanged glutathione level and increased level of malondialdehyde (P < 0.001), which indicates that pesticide sprayers may have suffered from oxidative stress. Decreased acetyl-cholinesterase levels (P < 0.001) in sprayers compared to the controls suggest inhibition of cholinesterase activity. The present study shows that pesticide toxicity might lead to oxidative stress and airway narrowing resulting in decreased peak expiratory flow rate.
- Published
- 2006
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