1. Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution.
- Author
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Hsu, Wen-Hua, Yang, Cheng-Chang, Tsai, Cheng-Yu, Majumdar, Arnab, Lee, Kang-Yun, Feng, Po-Hao, Tseng, Chien-Hua, Chen, Kuan-Yuan, Kang, Jiunn-Horng, Lee, Hsin-Chien, Wu, Cheng-Jung, Kuan, Yi-Chun, and Liu, Wen-Te
- Subjects
SLEEP apnea syndromes ,WATER distribution ,FAT ,BODIES of water ,BODY mass index ,ODDS ratio - Abstract
Obstructive sleep apnea (OSA) with a low arousal threshold (low-ArTH) phenotype can cause minor respiratory events that exacerbate sleep fragmentation. Although anthropometric features may affect the risk of low-ArTH OSA, the associations and underlying mechanisms require further investigation. This study investigated the relationships of body fat and water distribution with polysomnography parameters by using data from a sleep center database. The derived data were classified as those for low-ArTH in accordance with criteria that considered oximetry and the frequency and type fraction of respiratory events and analyzed using mean comparison and regression approaches. The low-ArTH group members (n = 1850) were significantly older and had a higher visceral fat level, body fat percentage, trunk-to-limb fat ratio, and extracellular-to-intracellular (E–I) water ratio compared with the non-OSA group members (n = 368). Significant associations of body fat percentage (odds ratio [OR]: 1.58, 95% confident interval [CI]: 1.08 to 2.3, p < 0.05), trunk-to-limb fat ratio (OR: 1.22, 95% CI: 1.04 to 1.43, p < 0.05), and E–I water ratio (OR: 1.32, 95% CI: 1.08 to 1.62, p < 0.01) with the risk of low-ArTH OSA were noted after adjustments for sex, age, and body mass index. These observations suggest that increased truncal adiposity and extracellular water are associated with a higher risk of low-ArTH OSA. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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