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Background: Post‐stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after a stroke. Animal experiments have indicated that serum S‐100β levels are closely related to anxiety disorder. No clinical study has been done to explore the relationship between serum S‐100β levels and anxiety symptoms in patients with acute stroke. The aim of our study was to investigate the association between serum S‐100β levels and PSA. Methods: One hundred twenty‐six acute stroke patients were recruited and followed up for 1 month. Blood samples were collected within 24 h after admission. The levels of serum S‐100β were measured by enzyme‐linked immunosorbent assays. Patients with significant clinical symptoms of anxiety and a Hamilton Anxiety Rating Scale score >7 at 1 month after stroke were diagnosed as PSA. Results: Serum S‐100β levels in the non‐PSA group were lower than the PSA group (838.97 (678.20–993.59) ng/L vs. 961.87 (796.09–1479.59) ng/L, Z = −2.661, P = 0.008). In multivariate analyses, we found that decreased risk of PSA was associated with low tertile serum S‐100β levels (≤753.8 ng/L, OR 0.062, 95% CI 0.008–0.475, P = 0.007). Conclusions: Low serum S‐100β levels at admission may be associated with the decreased risk of PSA. [ABSTRACT FROM AUTHOR]

Objective: It is unknown whether prediabetes is a predictor of poststroke depression (PSD). We aimed to explore the relationship between prediabetes and PSD in Chinese patients with acute ischemic stroke.Methods: This is a prospective cohort study, and a total of 358 patients with acute ischemic stroke were recruited and enrolled. Patients were divided into 3 groups: normal glucose group (NGT, n = 96), prediabetes group (preDM, n = 134, impaired fasting glucose (IFG), and/or impaired glucose tolerance (IGT) and/or HbA1c (A1c) 5.7%-6.4%), and the diabetes mellitus group (DM, n = 128). At 1 month after stroke, patients with a Hamilton Depression Scale score of ≥8 were diagnosed as PSD.Results: In post hoc comparisons, the risk of PSD in patients with diabetes and prediabetes was higher than patients with NGT (37.5% vs 31.3% vs 14.6%, P = .001). Compared with NGT, the incidence rate of PSD in patients with prediabetes with HbA1c 5.7% to 6.4% and patients with prediabetes with IFG/IGT + HbA1c 5.7% to 6.4% was higher (35.3% vs 14.6%, 38.0% vs 14.6%; P = .006; P = .003, respectively). In logistic regression, prediabetes with HbA1c 5.7% to 6.4% and prediabetes with IFG/IGT + HbA1c 5.7% to 6.4% were a significant independent predictor of PSD after adjusting for potential confounding factors, with odd ratios of 1.731 and 1.978, respectively.Conclusions: Our study showed that prediabetes was associated with PSD and may predict its development at 1 month poststroke. In prediabetes subgroups, patients with HbA1c 5.7% to 6.4% were more likely to develop PSD compared to NGT and IFG/IGT groups. [ABSTRACT FROM AUTHOR]