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1. Update to RIFM fragrance ingredient safety assessment, linalyl acetate, CAS registry number 115-95-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Endpoint Determination, Monoterpenes toxicity, Monoterpenes chemistry, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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2. RIFM fragrance ingredient safety assessment, bicyclo[2.2.1]heptan-2-ol, 1,3,3-trimethyl-, benzoate, CAS Registry Number 55066-54-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Benzoates toxicity, Benzoates chemistry, Toxicity Tests, Endpoint Determination, Bridged Bicyclo Compounds toxicity, Bridged Bicyclo Compounds chemistry, Consumer Product Safety, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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3. RIFM fragrance ingredient safety assessment, phenethyl alcohol, CAS Registry Number 60-12-8.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Phenylethyl Alcohol toxicity, Phenylethyl Alcohol analogs & derivatives, Phenylethyl Alcohol chemistry, Endpoint Determination, Toxicity Tests, Consumer Product Safety, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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4. Update to RIFM fragrance ingredient safety assessment, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-5-yl pivalate, CAS Registry Number 68039-45-2.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Consumer Product Safety, Indenes toxicity, Indenes chemistry, Endpoint Determination, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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5. RIFM fragrance ingredient safety assessment, allyl heptanoate, CAS registry number 142-19-8.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Consumer Product Safety, Toxicity Tests, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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6. RIFM fragrance ingredient safety assessment, allyl cinnamate, CAS Registry number 1866-31-5.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Consumer Product Safety, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Cinnamates toxicity, Cinnamates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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7. Update to RIFM fragrance ingredient safety assessment, 1,3,3-trimethyl-2-norbornanyl acetate, CAS registry number 13851-11-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Acetates toxicity, Acetates chemistry, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Norbornanes toxicity, Norbornanes chemistry, Risk Assessment, Toxicity Tests, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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8. RIFM fragrance ingredient safety assessment, 1,3-cyclohexadiene-1-carboxylic acid, 4,6,6-trimethyl-, ethyl ester, CAS Registry Number 100520-15-8.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Carboxylic Acids toxicity, Carboxylic Acids chemistry, Consumer Product Safety, Cyclohexenes toxicity, Cyclohexenes chemistry, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Esters chemistry, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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9. Update to RIFM fragrance ingredient safety assessment, hexyl butyrate, CAS Registry Number 2639-63-6.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Butyrates toxicity, Butyrates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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10. RIFM fragrance ingredient safety assessment, veratraldehyde, CAS Registry Number 120-14-9.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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11. RIFM fragrance ingredient safety assessment, 1,4-bis(ethoxymethyl)cyclohexane, CAS Registry Number 54889-63-3.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Endpoint Determination, Consumer Product Safety, Databases, Chemical, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Cyclohexanes toxicity, Cyclohexanes chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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12. Update to RIFM fragrance ingredient safety assessment, benzenepropanol, a,ß-dimethyl-, CAS Registry Number 56836-93-2.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, No-Observed-Adverse-Effect Level, Endpoint Determination, Databases, Chemical, Propanols toxicity, Propanols chemistry, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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13. RIFM fragrance ingredient safety assessment, o-phenyl anisole, CAS registry number 86-26-0.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Consumer Product Safety, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Anisoles toxicity, Anisoles chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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14. Update to RIFM fragrance ingredient safety assessment, octyl butyrate, CAS Registry Number 110-39-4.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Butyrates toxicity, Butyrates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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15. Update to RIFM fragrance ingredient safety assessment, (Z)-octadec-9-enol, CAS registry number 143-28-2.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Consumer Product Safety, Endpoint Determination, Toxicity Tests, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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16. RIFM fragrance ingredient safety assessment, allyl α-ionone, CAS Registry Number 79-78-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Norisoprenoids toxicity, Norisoprenoids chemistry, Endpoint Determination, Consumer Product Safety, No-Observed-Adverse-Effect Level, Toxicity Tests, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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17. RIFM fragrance ingredient safety assessment, 3,7-dimethyl-7-methoxyoctan-2-ol, CAS registry number 41890-92-0.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Toxicity Tests, Endpoint Determination, Consumer Product Safety, Databases, Chemical, No-Observed-Adverse-Effect Level, Octanols toxicity, Octanols chemistry, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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18. RIFM fragrance ingredient safety assessment, 2-heptanol, 3,6-dimethyl-, CAS registry number 1247790-47-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Heptanol analogs & derivatives, Heptanol chemistry, Heptanol toxicity, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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19. Update to RIFM fragrance ingredient safety assessment, lauryl acetate, CAS Registry Number 112-66-3.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Acetates toxicity, Acetates chemistry, Toxicity Tests, No-Observed-Adverse-Effect Level, Endpoint Determination, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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20. RIFM fragrance ingredient safety assessment, 2,2-dimethyl-3-phenylpropanol, CAS registry number 13351-61-6.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Propanols toxicity, Propanols chemistry, Risk Assessment, Toxicity Tests, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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21. RIFM fragrance ingredient safety assessment, linalyl propionate, CAS registry number 144-39-8.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Consumer Product Safety, Propionates toxicity, Propionates chemistry, Toxicity Tests, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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22. RIFM fragrance ingredient safety assessment, 2-hydroxybenzoic acid, CAS Registry Number 69-72-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Salicylic Acid chemistry, Salicylic Acid toxicity, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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23. RIFM fragrance ingredient safety assessment, cis-3-hexenal, CAS Registry Number 6789-80-6.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, No-Observed-Adverse-Effect Level, Toxicity Tests, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants, Aldehydes toxicity, Aldehydes chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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24. RIFM fragrance ingredient safety assessment, 2-methyl-5-phenylpentanol, CAS Registry Number 25634-93-9.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Consumer Product Safety, Pentanols toxicity, Pentanols chemistry, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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25. RIFM natural complex substance (NCS) fragrance ingredient safety assessment, lavandin abrialis, CAS registry number 8022-15-9, RIFM ID 1048554.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Consumer Product Safety, Endpoint Determination, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants analysis
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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26. RIFM fragrance ingredient safety assessment, propanoic acid, 2-methyl-, cyclohexyl ester, CAS Registry Number 1129-47-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Endpoint Determination, Consumer Product Safety, Toxicity Tests, Propionates toxicity, Propionates chemistry, No-Observed-Adverse-Effect Level, Esters toxicity, Esters chemistry, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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27. RIFM fragrance ingredient safety assessment, tetrahydrogeranial, CAS Registry Number 5988-91-0.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Endpoint Determination, Toxicity Tests, Consumer Product Safety, Monoterpenes toxicity, Monoterpenes chemistry, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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28. RIFM fragrance ingredient safety assessment, 5-methylfurfural, CAS registry number 620-02-0.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Consumer Product Safety, Endpoint Determination, Toxicity Tests, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants, Furaldehyde toxicity, Furaldehyde analogs & derivatives, Furaldehyde chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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29. RIFM fragrance ingredient safety assessment, isobornyl acetate, CAS Registry Number 125-12-2.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Acetates toxicity, Acetates chemistry, Endpoint Determination, Consumer Product Safety, No-Observed-Adverse-Effect Level, Toxicity Tests, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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30. Update to RIFM fragrance ingredient safety assessment, β-methylphenethyl alcohol, CAS Registry Number 1123-85-9.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, No-Observed-Adverse-Effect Level, Toxicity Tests, Databases, Chemical, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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31. RIFM fragrance ingredient safety assessment, furfural, CAS Registry Number 98-01-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Furaldehyde toxicity, Furaldehyde analogs & derivatives, Furaldehyde chemistry, Endpoint Determination, Consumer Product Safety, Toxicity Tests, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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32. Update to RIFM fragrance ingredient safety assessment, octyl acetate, CAS Registry Number 112-14-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, No-Observed-Adverse-Effect Level, Consumer Product Safety, Toxicity Tests, Endpoint Determination, Perfume toxicity, Perfume chemistry, Odorants, Acetates toxicity, Acetates chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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33. Update to RIFM fragrance ingredient safety assessment, 1-oxaspiro[4.5]decan-2-one, 8-methyl-, CAS Registry number 94201-19-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Spiro Compounds toxicity, Spiro Compounds chemistry, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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34. RIFM fragrance ingredient safety assessment, trichloromethyl phenyl carbinyl acetate, CAS Registry number 90-17-5.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Acetates toxicity, Acetates chemistry, Endpoint Determination, Toxicity Tests, No-Observed-Adverse-Effect Level, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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35. RIFM fragrance ingredient safety assessment, rotundone, CAS Registry Number 18374-76-0.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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36. Update to RIFM fragrance ingredient safety assessment, isopropyl butyrate, CAS Registry Number 638-11-9.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Toxicity Tests, Databases, Chemical, No-Observed-Adverse-Effect Level, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Butyrates toxicity, Butyrates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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37. Update to RIFM fragrance ingredient safety assessment, α-propylphenethyl alcohol, CAS registry number 705-73-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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38. Update to RIFM fragrance ingredient safety assessment, isopropyl acetate, CAS registry number 108-21-4.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Toxicity Tests, Endpoint Determination, Consumer Product Safety, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Acetates toxicity, Acetates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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39. RIFM fragrance ingredient safety assessment, ethyl salicylate, CAS Registry Number 118-61-6.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Endpoint Determination, Toxicity Tests, Consumer Product Safety, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants, Salicylates toxicity, Salicylates chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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40. Update to RIFM fragrance ingredient safety assessment, hexyl acetate, CAS registry number 142-92-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Toxicity Tests, No-Observed-Adverse-Effect Level, Consumer Product Safety, Databases, Chemical, Perfume toxicity, Perfume chemistry, Acetates toxicity, Acetates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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41. Update to RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS registry number 7492-44-6.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Acrolein toxicity, Acrolein chemistry, Acrolein analogs & derivatives, Toxicity Tests, Consumer Product Safety, Endpoint Determination, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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42. RIFM fragrance ingredient safety assessment, 7-isopropyl-1,4-dimethylazulene, CAS registry number 489-84-9.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Endpoint Determination, Consumer Product Safety, Toxicity Tests, No-Observed-Adverse-Effect Level, Azulenes, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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43. RIFM fragrance ingredient safety assessment, geranyl acetate, CAS registry number 105-87-3.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Consumer Product Safety, Toxicity Tests, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants, Acetates toxicity, Acetates chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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44. RIFM fragrance ingredient safety assessment, linalyl butyrate, CAS Registry Number 78-36-4.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Toxicity Tests, Consumer Product Safety, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants, Butyrates toxicity, Butyrates chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
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45. RIFM fragrance ingredient safety assessment, N-ethyl-N-(3-methylphenyl)propionamide, CAS Registry Number 179911-08-1.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Toxicity Tests, Consumer Product Safety, Databases, Chemical, No-Observed-Adverse-Effect Level, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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46. Update to RIFM fragrance ingredient safety assessment, octyl formate, CAS registry number 112-32-3.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Endpoint Determination, Toxicity Tests, No-Observed-Adverse-Effect Level, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Formates toxicity, Formates chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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47. Update to RIFM fragrance ingredient safety assessment, decyl acetate, CAS Registry Number 112-17-4.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Animals, Risk Assessment, Toxicity Tests, Endpoint Determination, No-Observed-Adverse-Effect Level, Consumer Product Safety, Perfume toxicity, Perfume chemistry, Odorants, Acetates toxicity, Acetates chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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48. Update to RIFM fragrance ingredient safety assessment, 4-phenyl-3-buten-2-ol, CAS registry number 17488-65-2.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Humans, Risk Assessment, Animals, Toxicity Tests, Endpoint Determination, Consumer Product Safety, No-Observed-Adverse-Effect Level, Databases, Chemical, Perfume toxicity, Perfume chemistry, Odorants
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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49. Update to RIFM fragrance ingredient safety assessment, methylheptenol, CAS Registry Number 1335-09-7.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Heptanol analogs & derivatives, Heptanol chemistry, Heptanol toxicity, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
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50. RIFM fragrance ingredient safety assessment, nonanoyl 4-hydroxy-3-methoxybenzylamide, CAS Registry Number 2444-46-4.

Author

Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Freidrich A, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Jones L, Joshi K, Lapczynski A, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, and Tokura Y

Subjects
Animals, Humans, Consumer Product Safety, Databases, Chemical, Endpoint Determination, No-Observed-Adverse-Effect Level, Risk Assessment, Toxicity Tests, Benzamides chemistry, Benzamides toxicity, Odorants, Perfume toxicity, Perfume chemistry
Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. RIFM staff are employees of the Research Institute for Fragrance Materials, Inc. (RIFM). The Expert Panel receives a small honorarium for time spent reviewing the subject work.

Published
2024
Full Text
View/download PDF

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