1. Profiles of Odorant Specific Performance in Olfactory Testing.
- Author
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Schlosser, Rodney J., Soler, Zachary M., Mace, Jess, Farrell, Nyssa, Rimmer, Ryan, Alt, Jeremiah A., Ramakrishnan, Vijay R., Edwards, Thomas S., and Smith, Timothy L.
- Subjects
NASAL polyps ,SMELL disorders ,TURPENTINE ,ETIOLOGY of diseases ,PATHOLOGICAL physiology - Abstract
Background: Olfactory dysfunction (OD) can occur from a variety of etiologies. However, there are few reports examining whether varying etiologies have unique profiles of psychophysical testing that may provide insight into the pathophysiology of OD. Methods: Adults with chronic rhinosinusitis with and without nasal polyps (CRSwNP/CRSsNP) and healthy control adults with no sinus complaints underwent olfactory assessment with Sniffin' Sticks. Profiles of identification and discrimination were compared between CRS and non-CRS subjects across the spectrum of OD. Results: Normosmics with or without CRS identified apple, pineapple, and turpentine less frequently than expected (range 52%-68% correct). Hyposmics with CRS correctly identified orange more frequently than control hyposmics (83%-93% vs 68% for controls) with similar findings for rose. Hyposmics of all cohorts were unable to identify apple (26%). Discrimination profiles were similar across the spectrum of OD and between diagnostic groups. Conclusions: Identification and discrimination rates of specific odorants may provide unique information regarding the etiology of OD, however psychophysical testing is a complex interplay of olfactory and trigeminal function, the strength of target odorant, distractor choices, and familiarity with odorants. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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